Issues in Response Assessment of Brain Tumor Chemotherapy

Brendan J. McCullough, John W. Henson

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Clinical management of brain tumors and investigations into new therapies requires the ability to assess repeatedly the response of disease to treatment. Magnetic resonance imaging (MRI) is the primary means of non-invasive tumor monitoring in neuro-oncology, but it is an indirect measure of the underlying pathophysiology. In this chapter, we will first discuss the methods and limitations of measurements in neuroimaging. Next, we will examine the evolving criteria meant to standardize and interpret changes in disease on MRI. Finally, we will review the imprecise relationship between imaging and disease.

Original languageEnglish (US)
Title of host publicationHandbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages13
ISBN (Print)9780128121009
StatePublished - Apr 24 2018
Externally publishedYes


  • Brain metastases
  • Brain tumor
  • Glioma
  • Magnetic resonance imaging
  • Neuro-oncology
  • Pseudo-progression
  • Pseudo-response
  • Response assessment

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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