Issues in Response Assessment of Brain Tumor Chemotherapy

Brendan J. McCullough; John W. Henson

doi:10.1016/B978-0-12-812100-9.00057-7

Issues in Response Assessment of Brain Tumor Chemotherapy

Brendan J. McCullough, John W. Henson

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Clinical management of brain tumors and investigations into new therapies requires the ability to assess repeatedly the response of disease to treatment. Magnetic resonance imaging (MRI) is the primary means of non-invasive tumor monitoring in neuro-oncology, but it is an indirect measure of the underlying pathophysiology. In this chapter, we will first discuss the methods and limitations of measurements in neuroimaging. Next, we will examine the evolving criteria meant to standardize and interpret changes in disease on MRI. Finally, we will review the imprecise relationship between imaging and disease.

Original language	English (US)
Title of host publication	Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	715-727
Number of pages	13
ISBN (Print)	9780128121009
DOIs	https://doi.org/10.1016/B978-0-12-812100-9.00057-7
State	Published - Apr 24 2018
Externally published	Yes

Keywords

Brain metastases
Brain tumor
Glioma
Magnetic resonance imaging
Neuro-oncology
Pseudo-progression
Pseudo-response
Response assessment

ASJC Scopus subject areas

Medicine(all)
Neuroscience(all)

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10.1016/B978-0-12-812100-9.00057-7

Cite this

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title = "Issues in Response Assessment of Brain Tumor Chemotherapy",

abstract = "Clinical management of brain tumors and investigations into new therapies requires the ability to assess repeatedly the response of disease to treatment. Magnetic resonance imaging (MRI) is the primary means of non-invasive tumor monitoring in neuro-oncology, but it is an indirect measure of the underlying pathophysiology. In this chapter, we will first discuss the methods and limitations of measurements in neuroimaging. Next, we will examine the evolving criteria meant to standardize and interpret changes in disease on MRI. Finally, we will review the imprecise relationship between imaging and disease.",

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T1 - Issues in Response Assessment of Brain Tumor Chemotherapy

AU - McCullough, Brendan J.

AU - Henson, John W.

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N2 - Clinical management of brain tumors and investigations into new therapies requires the ability to assess repeatedly the response of disease to treatment. Magnetic resonance imaging (MRI) is the primary means of non-invasive tumor monitoring in neuro-oncology, but it is an indirect measure of the underlying pathophysiology. In this chapter, we will first discuss the methods and limitations of measurements in neuroimaging. Next, we will examine the evolving criteria meant to standardize and interpret changes in disease on MRI. Finally, we will review the imprecise relationship between imaging and disease.

AB - Clinical management of brain tumors and investigations into new therapies requires the ability to assess repeatedly the response of disease to treatment. Magnetic resonance imaging (MRI) is the primary means of non-invasive tumor monitoring in neuro-oncology, but it is an indirect measure of the underlying pathophysiology. In this chapter, we will first discuss the methods and limitations of measurements in neuroimaging. Next, we will examine the evolving criteria meant to standardize and interpret changes in disease on MRI. Finally, we will review the imprecise relationship between imaging and disease.

KW - Brain metastases

KW - Brain tumor

KW - Glioma

KW - Magnetic resonance imaging

KW - Neuro-oncology

KW - Pseudo-progression

KW - Pseudo-response

KW - Response assessment

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DO - 10.1016/B978-0-12-812100-9.00057-7

M3 - Chapter

AN - SCOPUS:85054618890

SN - 9780128121009

SP - 715

EP - 727

BT - Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy

PB - Elsevier Inc.

ER -

Issues in Response Assessment of Brain Tumor Chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

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