L-selectin in inflammation, infection and immunity

Nikolai A. Raffler, Jesús Rivera-Nieves, Klaus Ley

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


L-selectin (CD62L) is an adhesion molecule expressed on most leukocytes. This article describes recent findings of L-selectin's role in the recruitment of T cells to sites of inflammation and its contribution to the acquisition of immunologic memory. We discuss the regulation of L-selectin expression during and after the activation of T cells and its physiological function during the course of inflammation. Different disease models and current approaches for drug development are reviewed.

Original languageEnglish (US)
Pages (from-to)213-220
Number of pages8
JournalDrug Discovery Today: Therapeutic Strategies
Issue number3
StatePublished - 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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