L-selectin in inflammation, infection and immunity

Nikolai A. Raffler; Jesús Rivera-Nieves; Klaus Ley

doi:10.1016/j.ddstr.2005.08.012

L-selectin in inflammation, infection and immunity

Nikolai A. Raffler, Jesús Rivera-Nieves, Klaus Ley

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

L-selectin (CD62L) is an adhesion molecule expressed on most leukocytes. This article describes recent findings of L-selectin's role in the recruitment of T cells to sites of inflammation and its contribution to the acquisition of immunologic memory. We discuss the regulation of L-selectin expression during and after the activation of T cells and its physiological function during the course of inflammation. Different disease models and current approaches for drug development are reviewed.

Original language	English (US)
Pages (from-to)	213-220
Number of pages	8
Journal	Drug Discovery Today: Therapeutic Strategies
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/j.ddstr.2005.08.012
State	Published - 2005
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery

Access to Document

10.1016/j.ddstr.2005.08.012

Cite this

@article{ef55afc034374dedb54cc6c4ddcb2f69,

title = "L-selectin in inflammation, infection and immunity",

abstract = "L-selectin (CD62L) is an adhesion molecule expressed on most leukocytes. This article describes recent findings of L-selectin's role in the recruitment of T cells to sites of inflammation and its contribution to the acquisition of immunologic memory. We discuss the regulation of L-selectin expression during and after the activation of T cells and its physiological function during the course of inflammation. Different disease models and current approaches for drug development are reviewed.",

author = "Raffler, {Nikolai A.} and Jes{\'u}s Rivera-Nieves and Klaus Ley",

year = "2005",

doi = "10.1016/j.ddstr.2005.08.012",

language = "English (US)",

volume = "2",

pages = "213--220",

journal = "Drug Discovery Today: Therapeutic Strategies",

issn = "1740-6773",

publisher = "Elsevier Limited",

number = "3",

}

TY - JOUR

T1 - L-selectin in inflammation, infection and immunity

AU - Raffler, Nikolai A.

AU - Rivera-Nieves, Jesús

AU - Ley, Klaus

PY - 2005

Y1 - 2005

N2 - L-selectin (CD62L) is an adhesion molecule expressed on most leukocytes. This article describes recent findings of L-selectin's role in the recruitment of T cells to sites of inflammation and its contribution to the acquisition of immunologic memory. We discuss the regulation of L-selectin expression during and after the activation of T cells and its physiological function during the course of inflammation. Different disease models and current approaches for drug development are reviewed.

AB - L-selectin (CD62L) is an adhesion molecule expressed on most leukocytes. This article describes recent findings of L-selectin's role in the recruitment of T cells to sites of inflammation and its contribution to the acquisition of immunologic memory. We discuss the regulation of L-selectin expression during and after the activation of T cells and its physiological function during the course of inflammation. Different disease models and current approaches for drug development are reviewed.

UR - http://www.scopus.com/inward/record.url?scp=27144446771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27144446771&partnerID=8YFLogxK

U2 - 10.1016/j.ddstr.2005.08.012

DO - 10.1016/j.ddstr.2005.08.012

M3 - Review article

AN - SCOPUS:27144446771

SN - 1740-6773

VL - 2

SP - 213

EP - 220

JO - Drug Discovery Today: Therapeutic Strategies

JF - Drug Discovery Today: Therapeutic Strategies

IS - 3

ER -

L-selectin in inflammation, infection and immunity

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this