Lack of insight in schizophrenia: Impact on treatment adherence

Peter F. Buckley, Donna A. Wirshing, Prameet Bhushan, Joseph M. Pierre, Seth A. Resnick, William C. Wirshing

Research output: Contribution to journalReview articlepeer-review

136 Scopus citations


People with schizophrenia commonly lack insight, that is, they are unaware of their illness and the consequences thereof. One of the most important consequences of lack of insight is a failure to recognise the need for treatment, leading to treatment nonadherence. With several scales that now enable objective measurement of insight, it is possible to examine correlates of insight change, including course of illness and treatment adherence. Specific interventions, both pharmacological and psychotherapeutic, have been developed to enhance illness insight and treatment adherence. The extent to which second-generation antipsychotic medications, including a recently released long-acting formulation, improve insight and/or enhance treatment adherence remains to be determined.

Original languageEnglish (US)
Pages (from-to)129-141
Number of pages13
JournalCNS Drugs
Issue number2
StatePublished - 2007
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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