Abstract
The effects of lanthanum on the contraction induced by the protein kinase C activator, 12-0-tetradecanoylphorbol-13-ac-etate (TPA) were studied in femoral artery rings from stroke- prone, spontaneously hypertensive rats (SHRSP) and normo- tensive Wistar-Kyoto rats (WKY). When exposed to a calcium- free buffer containing 1 mmol/l EGTA, the femoral artery rings from SHRSP and WKY, pre-contracted with TPA (10-6mol/l), relaxed by 52 and 24%, respectively. Treatment of the rings in this calcium-free buffer with 2.6 mmol/l lanthanum significantly potentiated the TPA-induced contractions in vascular rings from WKY (49%) and SHRSP (136%). Potentiation by lanthanum of the TPA-induced contraction in the absence of extracellular calcium suggests that this cation is acting intracellularly to increase protein kinase C activity. The in-creased vascular responsiveness of SHRSP to lanthanum may reflect an abnormality in protein kinase C activation in vascular smooth muscle of genetically hypertensive rats.
Original language | English (US) |
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Pages (from-to) | S146-S147 |
Journal | Journal of Hypertension, Supplement |
Volume | 7 |
State | Published - 1989 |
Externally published | Yes |
Keywords
- Calcium
- Femoral artery
- Genetic hypertension
- Lanthanum
- Protein kinase C activators
ASJC Scopus subject areas
- Internal Medicine
- Physiology
- Cardiology and Cardiovascular Medicine