TY - JOUR
T1 - Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD
AU - Sajikumar, Sreedharan
AU - Frey, Julietta U.
N1 - Funding Information:
We thank Drs. Denise Manahan-Vaughan and Seth Grant for their critical comments on the manuscript. Parts of this work were presented in an initial abstract form as a poster at the Society for Neuroscience Meeting in New Orleans 11/2003 and at the 29th Göttingen Neurobiology Conference 6/2003. This work was supported by a grant of the VolkswagenStiftung I/77 922 and the EU Framework V “Nappy” to J.U.F.
PY - 2004/7
Y1 - 2004/7
N2 - Protein synthesis-dependent, synapse input-specific late phases of long-term potentiation (LTP) and depression (LTD) may underlie memory formation at the cellular level. Recently, it was described that the induction of LTP can mark a specifically activated synapse by a synaptic tag to capture synapse non-specific plasticity-related proteins (PRPs) and thus maintaining input-specific LTP for prolonged periods. Here we show in rat hippocampal slices in vitro, that the induction of protein synthesis-dependent late-LTD is also characterized by synaptic tagging and that heterosynaptic induction of either LTD or LTP on two sets of independent synaptic inputs S1 and S2 can lead to late-associative interactions: early-LTD in S2 was transformed into a late-LTD, if late-LTP was induced in S1. The synthesis of process-independent PRPs by late-LTP in S1 was sufficient to transform early- into late-LTD in S2 when process-specific synaptic tags were set. We name this new associative property of cellular information processing 'cross-tagging.'
AB - Protein synthesis-dependent, synapse input-specific late phases of long-term potentiation (LTP) and depression (LTD) may underlie memory formation at the cellular level. Recently, it was described that the induction of LTP can mark a specifically activated synapse by a synaptic tag to capture synapse non-specific plasticity-related proteins (PRPs) and thus maintaining input-specific LTP for prolonged periods. Here we show in rat hippocampal slices in vitro, that the induction of protein synthesis-dependent late-LTD is also characterized by synaptic tagging and that heterosynaptic induction of either LTD or LTP on two sets of independent synaptic inputs S1 and S2 can lead to late-associative interactions: early-LTD in S2 was transformed into a late-LTD, if late-LTP was induced in S1. The synthesis of process-independent PRPs by late-LTP in S1 was sufficient to transform early- into late-LTD in S2 when process-specific synaptic tags were set. We name this new associative property of cellular information processing 'cross-tagging.'
KW - Cross-tagging
KW - Heterosynaptic late-associativity
KW - Long-term depression
KW - Long-term potentiation
KW - Protein synthesis
KW - Synaptic tagging
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U2 - 10.1016/j.nlm.2004.03.003
DO - 10.1016/j.nlm.2004.03.003
M3 - Article
C2 - 15183167
AN - SCOPUS:2942528888
SN - 1074-7427
VL - 82
SP - 12
EP - 25
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
IS - 1
ER -