Leaking chemokines confuse neutrophils

Alex Marki, Klaus Ley

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The physical integrity of endothelial cells (ECs) lining the blood vessels regulates the inflammatory response. Both innate immunity and inflammatory disorders hinge on the EC-neutrophil interaction. Neutrophil binding, rolling, and migrating along and between ECs is associated with vascular permeability. In this issue of the JCI, Owen-Woods et al. tracked neutrophils in vivo in venules of mouse striated muscle and revealed how endothelial permeability can affect neutrophil trafficking. Strikingly, many neutrophils that migrated between EC junctions were able to rejoin the blood circulation. Further, the chemokine and neutrophil chemoattractant, CXCL1, drove this reverse transendothelial migration (rTEM). This paradigm-shifting study provides a mechanism for distal organ damage as well as an explanation for sepsis-associated acute respiratory distress syndrome.

Original languageEnglish (US)
Pages (from-to)2177-2179
Number of pages3
JournalJournal of Clinical Investigation
Issue number5
StatePublished - May 1 2020
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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