Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation

Zhichao Fan, Klaus Ley

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Integrins are a group of heterodimeric transmembrane receptors that play essential roles in cell-cell and cell-matrix interaction. Integrins are important in many physiological processes and diseases. Integrins acquire affinity to their ligand by undergoing molecular conformational changes called activation. Here we review the molecular biomechanics during conformational changes of integrins, integrin functions in leukocyte biorheology (adhesive functions during rolling and arrest) and molecules involved in integrin activation.

Original languageEnglish (US)
Pages (from-to)353-377
Number of pages25
JournalBiorheology
Volume52
Issue number5-6
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • GPCR
  • Kindlin-3
  • PSGL-1
  • RIAM
  • Rap-1
  • Talin

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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