Efficient syntheses of O-acyl Tyr-peptides allow chemical long-range ligation (O-acyl to N-acyl transfer) via each of 12- to 19-membered cyclic transition states. The results represent the first examples of successful isopeptide ligations starting from O-acyl Tyr-peptides.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Organic Chemistry|
|State||Published - Aug 2 2013|
- Molecular Structure
- Journal Article
- Research Support, Non-U.S. Gov't