Abstract
Efficient syntheses of O-acyl Tyr-peptides allow chemical long-range ligation (O-acyl to N-acyl transfer) via each of 12- to 19-membered cyclic transition states. The results represent the first examples of successful isopeptide ligations starting from O-acyl Tyr-peptides.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7455-61 |
| Number of pages | 7 |
| Journal | Journal of Organic Chemistry |
| Volume | 78 |
| Issue number | 15 |
| DOIs | |
| State | Published - Aug 2 2013 |
Keywords
- Molecular Structure
- Peptides
- Tyrosine
- Journal Article
- Research Support, Non-U.S. Gov't