Abstract
Dong et al. show that the loss of Lhx4 in mice results in the loss of rod bipolar cells and rod-connecting bipolar cells and in a visual defect resembling human congenital stationary night blindness. Lhx4, together with Isl1, acts upstream of Bhlhe23, Prdm8, Fezf2, and Lhx3 to regulate bipolar cell development.
Original language | English (US) |
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Article number | 108144 |
Journal | Cell Reports |
Volume | 32 |
Issue number | 11 |
DOIs | |
State | Published - Sep 15 2020 |
Keywords
- AII amacrine cells
- ERG
- GABAergic ACs
- LIM-homeodomain transcription factor
- congenital stationary night blindness
- rod bipolar cells
- rod-connecting CBCs
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology