LIM-Homeodomain Transcription Factor LHX4 Is Required for the Differentiation of Retinal Rod Bipolar Cells and OFF-Cone Bipolar Subtypes

Xuhui Dong; Hua Yang; Xiangtian Zhou; Xiaoling Xie; Dongliang Yu; Luming Guo; Mei Xu; Wenjun Zhang; Guoqing Liang; Lin Gan

doi:10.1016/j.celrep.2020.108144

LIM-Homeodomain Transcription Factor LHX4 Is Required for the Differentiation of Retinal Rod Bipolar Cells and OFF-Cone Bipolar Subtypes

Xuhui Dong
, Hua Yang
, Xiangtian Zhou
, Xiaoling Xie
, Dongliang Yu
, Luming Guo
, Mei Xu
, Wenjun Zhang
, Guoqing Liang
, Lin Gan

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Dong et al. show that the loss of Lhx4 in mice results in the loss of rod bipolar cells and rod-connecting bipolar cells and in a visual defect resembling human congenital stationary night blindness. Lhx4, together with Isl1, acts upstream of Bhlhe23, Prdm8, Fezf2, and Lhx3 to regulate bipolar cell development.

Original language	English (US)
Article number	108144
Journal	Cell Reports
Volume	32
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2020.108144
State	Published - Sep 15 2020

Keywords

AII amacrine cells
ERG
GABAergic ACs
LIM-homeodomain transcription factor
congenital stationary night blindness
rod bipolar cells
rod-connecting CBCs

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2020.108144

Cite this

@article{db1552b8355245bfb96c15f87adb58de,

title = "LIM-Homeodomain Transcription Factor LHX4 Is Required for the Differentiation of Retinal Rod Bipolar Cells and OFF-Cone Bipolar Subtypes",

abstract = "Dong et al. show that the loss of Lhx4 in mice results in the loss of rod bipolar cells and rod-connecting bipolar cells and in a visual defect resembling human congenital stationary night blindness. Lhx4, together with Isl1, acts upstream of Bhlhe23, Prdm8, Fezf2, and Lhx3 to regulate bipolar cell development.",

keywords = "AII amacrine cells, ERG, GABAergic ACs, LIM-homeodomain transcription factor, congenital stationary night blindness, rod bipolar cells, rod-connecting CBCs",

author = "Xuhui Dong and Hua Yang and Xiangtian Zhou and Xiaoling Xie and Dongliang Yu and Luming Guo and Mei Xu and Wenjun Zhang and Guoqing Liang and Lin Gan",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = sep,

day = "15",

doi = "10.1016/j.celrep.2020.108144",

language = "English (US)",

volume = "32",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier BV",

number = "11",

}

TY - JOUR

T1 - LIM-Homeodomain Transcription Factor LHX4 Is Required for the Differentiation of Retinal Rod Bipolar Cells and OFF-Cone Bipolar Subtypes

AU - Dong, Xuhui

AU - Yang, Hua

AU - Zhou, Xiangtian

AU - Xie, Xiaoling

AU - Yu, Dongliang

AU - Guo, Luming

AU - Xu, Mei

AU - Zhang, Wenjun

AU - Liang, Guoqing

AU - Gan, Lin

PY - 2020/9/15

Y1 - 2020/9/15

N2 - Dong et al. show that the loss of Lhx4 in mice results in the loss of rod bipolar cells and rod-connecting bipolar cells and in a visual defect resembling human congenital stationary night blindness. Lhx4, together with Isl1, acts upstream of Bhlhe23, Prdm8, Fezf2, and Lhx3 to regulate bipolar cell development.

AB - Dong et al. show that the loss of Lhx4 in mice results in the loss of rod bipolar cells and rod-connecting bipolar cells and in a visual defect resembling human congenital stationary night blindness. Lhx4, together with Isl1, acts upstream of Bhlhe23, Prdm8, Fezf2, and Lhx3 to regulate bipolar cell development.

KW - AII amacrine cells

KW - ERG

KW - GABAergic ACs

KW - LIM-homeodomain transcription factor

KW - congenital stationary night blindness

KW - rod bipolar cells

KW - rod-connecting CBCs

UR - https://www.scopus.com/pages/publications/85090746408

UR - https://www.scopus.com/pages/publications/85090746408#tab=citedBy

U2 - 10.1016/j.celrep.2020.108144

DO - 10.1016/j.celrep.2020.108144

M3 - Article

C2 - 32937137

AN - SCOPUS:85090746408

SN - 2211-1247

VL - 32

JO - Cell Reports

JF - Cell Reports

IS - 11

M1 - 108144

ER -

LIM-Homeodomain Transcription Factor LHX4 Is Required for the Differentiation of Retinal Rod Bipolar Cells and OFF-Cone Bipolar Subtypes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this