Linking Hebb's coincidence-detection to memory formation

Joseph Zhuo Tsien

Research output: Contribution to journalReview articlepeer-review

165 Scopus citations


The theoretical foundations of learning and memory were laid by Donald Hebb 50 years ago. Recent genetic experiments that enhanced coincidence-detection of the NMDA receptor (a molecular master-switch in implementing Hebb's rule) and that led to better learning and memory in adult animals have substantially validated Hebb's rule in memory formation in the brain.

Original languageEnglish (US)
Pages (from-to)266-273
Number of pages8
JournalCurrent Opinion in Neurobiology
Issue number2
StatePublished - Apr 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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