Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis

Shivum Lal; Shreya Gunji; Pankaj Ahluwalia; Ravindra Kolhe; Wendy B. Bollag; William D. Hill; Meghan E. McGee-Lawrence; Carlos M. Isales; Sadanand Fulzele

doi:10.1186/s12915-025-02383-9

Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis

Shivum Lal
, Shreya Gunji
, Pankaj Ahluwalia
, Ravindra Kolhe
, Wendy B. Bollag
, William D. Hill
, Meghan E. McGee-Lawrence
, Carlos M. Isales
, Sadanand Fulzele

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Musculoskeletal disorders (MSDs), notably sarcopenia and osteoporosis, profoundly affect aging individuals. This review explores lipid metabolism's role in age-related MSD pathophysiology, highlighting fatty acid uptake, lipid signaling, and lipotoxicity in muscle deterioration. It further addresses lipid-mediated regulation of osteoclasts, osteoblasts, and bone remodeling, emphasizing age-associated metabolic shifts exacerbating bone loss. Emerging therapeutic strategies targeting lipid pathways for MSD treatment are also discussed. This review integrates recent findings in muscle and bone lipid metabolism to deepen understanding of lipid dysregulation in musculoskeletal disorders and explore potential metabolic intervention strategies.

Original language	English (US)
Article number	265
Journal	BMC Biology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1186/s12915-025-02383-9
State	Published - Dec 2025

Keywords

Aging
Lipid Metabolism
Musculoskeletal
Osteoporosis
Sarcopenia

ASJC Scopus subject areas

Biotechnology
Structural Biology
Ecology, Evolution, Behavior and Systematics
Physiology
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
Plant Science
Developmental Biology
Cell Biology

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10.1186/s12915-025-02383-9

Cite this

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title = "Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis",

abstract = "Musculoskeletal disorders (MSDs), notably sarcopenia and osteoporosis, profoundly affect aging individuals. This review explores lipid metabolism's role in age-related MSD pathophysiology, highlighting fatty acid uptake, lipid signaling, and lipotoxicity in muscle deterioration. It further addresses lipid-mediated regulation of osteoclasts, osteoblasts, and bone remodeling, emphasizing age-associated metabolic shifts exacerbating bone loss. Emerging therapeutic strategies targeting lipid pathways for MSD treatment are also discussed. This review integrates recent findings in muscle and bone lipid metabolism to deepen understanding of lipid dysregulation in musculoskeletal disorders and explore potential metabolic intervention strategies.",

keywords = "Aging, Lipid Metabolism, Musculoskeletal, Osteoporosis, Sarcopenia",

author = "Shivum Lal and Shreya Gunji and Pankaj Ahluwalia and Ravindra Kolhe and Bollag, \{Wendy B.\} and Hill, \{William D.\} and McGee-Lawrence, \{Meghan E.\} and Isales, \{Carlos M.\} and Sadanand Fulzele",

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doi = "10.1186/s12915-025-02383-9",

language = "English (US)",

volume = "23",

journal = "BMC Biology",

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TY - JOUR

T1 - Lipid metabolism in age-related musculoskeletal disorders

T2 - insights into sarcopenia and osteoporosis

AU - Lal, Shivum

AU - Gunji, Shreya

AU - Ahluwalia, Pankaj

AU - Kolhe, Ravindra

AU - Bollag, Wendy B.

AU - Hill, William D.

AU - McGee-Lawrence, Meghan E.

AU - Isales, Carlos M.

AU - Fulzele, Sadanand

N1 - Publisher Copyright: © The Author(s) 2025.

PY - 2025/12

Y1 - 2025/12

N2 - Musculoskeletal disorders (MSDs), notably sarcopenia and osteoporosis, profoundly affect aging individuals. This review explores lipid metabolism's role in age-related MSD pathophysiology, highlighting fatty acid uptake, lipid signaling, and lipotoxicity in muscle deterioration. It further addresses lipid-mediated regulation of osteoclasts, osteoblasts, and bone remodeling, emphasizing age-associated metabolic shifts exacerbating bone loss. Emerging therapeutic strategies targeting lipid pathways for MSD treatment are also discussed. This review integrates recent findings in muscle and bone lipid metabolism to deepen understanding of lipid dysregulation in musculoskeletal disorders and explore potential metabolic intervention strategies.

AB - Musculoskeletal disorders (MSDs), notably sarcopenia and osteoporosis, profoundly affect aging individuals. This review explores lipid metabolism's role in age-related MSD pathophysiology, highlighting fatty acid uptake, lipid signaling, and lipotoxicity in muscle deterioration. It further addresses lipid-mediated regulation of osteoclasts, osteoblasts, and bone remodeling, emphasizing age-associated metabolic shifts exacerbating bone loss. Emerging therapeutic strategies targeting lipid pathways for MSD treatment are also discussed. This review integrates recent findings in muscle and bone lipid metabolism to deepen understanding of lipid dysregulation in musculoskeletal disorders and explore potential metabolic intervention strategies.

KW - Aging

KW - Lipid Metabolism

KW - Musculoskeletal

KW - Osteoporosis

KW - Sarcopenia

UR - https://www.scopus.com/pages/publications/105013889541

UR - https://www.scopus.com/pages/publications/105013889541#tab=citedBy

U2 - 10.1186/s12915-025-02383-9

DO - 10.1186/s12915-025-02383-9

M3 - Review article

C2 - 40846955

AN - SCOPUS:105013889541

SN - 1741-7007

VL - 23

JO - BMC Biology

JF - BMC Biology

IS - 1

M1 - 265

ER -

Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis

Abstract

Keywords

ASJC Scopus subject areas

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