Abstract
The response of parenchymal microglia to interferon-gamma (IFN-γ) varies across the brain. To ask if local neurochemicals contribute to site-specific control, the influence of substance P (SP) and glutamate was evaluated in brainstem vs. hippocampus. In brainstem, stereotaxic injection of SP increased class II MHC upregulation by IFN-γ, while a SP receptor antagonist (Spantide I) prevented it. In hippocampus, where the baseline response to IFN-γ was lower, SP was ineffective, but blocking glutamate enhanced the response in a proportion of rats. Attempts to understand and control immune activity in the CNS should take the local neurochemical environment into account.
Original language | English (US) |
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Pages (from-to) | 136-146 |
Number of pages | 11 |
Journal | Journal of Neuroimmunology |
Volume | 116 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1 2001 |
Keywords
- Brainstem
- Class II MHC
- Hippocampus
- Interferon-γ
- MK-801
- Microglia
- NMDA receptors
- Neural-immune interactions
- Rat
- Spantide
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology