Long non-coding RNA hotair is targeted and regulated by MIR-141 in human cancer cells

Takeshi Chiyomaru; Shinichiro Fukuhara; Sharanjot Saini; Shahana Majid; Guoren Deng; Varahram Shahryari; Inik Chang; Yuichiro Tanaka; Hideki Enokida; Masayuki Nakagawa; Rajvir Dahiya; Soichiro Yamamura

doi:10.1074/jbc.M113.488593

Long non-coding RNA hotair is targeted and regulated by MIR-141 in human cancer cells

Takeshi Chiyomaru
, Shinichiro Fukuhara
, Sharanjot Saini
, Shahana Majid
, Guoren Deng
, Varahram Shahryari
, Inik Chang
, Yuichiro Tanaka
, Hideki Enokida
, Masayuki Nakagawa
, Rajvir Dahiya
, Soichiro Yamamura

Research output: Contribution to journal › Article › peer-review

191 Scopus citations

Abstract

Background: Silencing of long non-coding RNA (lncRNA) by microRNA (miRNA) has only been recently observed. Results: miR-141 binds to HOTAIR and suppresses its oncogenic function in Ago2 (Argounaute2). Conclusion: miR-141 targets and silences HOTAIR in an Ago2-dependent manner in cancer cells. Significance: Our results suggest that regulation of lncRNA expression by miRNA plays essential roles in gene expression and cellular functions.

Original language	English (US)
Pages (from-to)	12550-12565
Number of pages	16
Journal	Journal of Biological Chemistry
Volume	289
Issue number	18
DOIs	https://doi.org/10.1074/jbc.M113.488593
State	Published - 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.488593

Cite this

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title = "Long non-coding RNA hotair is targeted and regulated by MIR-141 in human cancer cells",

abstract = "Background: Silencing of long non-coding RNA (lncRNA) by microRNA (miRNA) has only been recently observed. Results: miR-141 binds to HOTAIR and suppresses its oncogenic function in Ago2 (Argounaute2). Conclusion: miR-141 targets and silences HOTAIR in an Ago2-dependent manner in cancer cells. Significance: Our results suggest that regulation of lncRNA expression by miRNA plays essential roles in gene expression and cellular functions.",

author = "Takeshi Chiyomaru and Shinichiro Fukuhara and Sharanjot Saini and Shahana Majid and Guoren Deng and Varahram Shahryari and Inik Chang and Yuichiro Tanaka and Hideki Enokida and Masayuki Nakagawa and Rajvir Dahiya and Soichiro Yamamura",

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doi = "10.1074/jbc.M113.488593",

language = "English (US)",

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T1 - Long non-coding RNA hotair is targeted and regulated by MIR-141 in human cancer cells

AU - Chiyomaru, Takeshi

AU - Fukuhara, Shinichiro

AU - Saini, Sharanjot

AU - Majid, Shahana

AU - Deng, Guoren

AU - Shahryari, Varahram

AU - Chang, Inik

AU - Tanaka, Yuichiro

AU - Enokida, Hideki

AU - Nakagawa, Masayuki

AU - Dahiya, Rajvir

AU - Yamamura, Soichiro

PY - 2014

Y1 - 2014

N2 - Background: Silencing of long non-coding RNA (lncRNA) by microRNA (miRNA) has only been recently observed. Results: miR-141 binds to HOTAIR and suppresses its oncogenic function in Ago2 (Argounaute2). Conclusion: miR-141 targets and silences HOTAIR in an Ago2-dependent manner in cancer cells. Significance: Our results suggest that regulation of lncRNA expression by miRNA plays essential roles in gene expression and cellular functions.

AB - Background: Silencing of long non-coding RNA (lncRNA) by microRNA (miRNA) has only been recently observed. Results: miR-141 binds to HOTAIR and suppresses its oncogenic function in Ago2 (Argounaute2). Conclusion: miR-141 targets and silences HOTAIR in an Ago2-dependent manner in cancer cells. Significance: Our results suggest that regulation of lncRNA expression by miRNA plays essential roles in gene expression and cellular functions.

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UR - https://www.scopus.com/pages/publications/84899754537#tab=citedBy

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DO - 10.1074/jbc.M113.488593

M3 - Article

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AN - SCOPUS:84899754537

SN - 0021-9258

VL - 289

SP - 12550

EP - 12565

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 18

ER -

Long non-coding RNA hotair is targeted and regulated by MIR-141 in human cancer cells

Abstract

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