TY - JOUR
T1 - Long-term follow-up and pattern of failure for T1-T2 glottic cancer after definitive radiation therapy
AU - Mourad, Waleed Fouad
AU - Hu, Kenneth S.
AU - Shourbaji, Rania A.
AU - Woode, Rudolph
AU - Harrison, Louis B.
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Purpose: To evaluate the impact of radiation therapy (RT) on the longterm outcomes and pattern of failure for T1-2 glottic cancer. Materials and Methods: This is a single-institution, retrospective study. From January (1997 to 2010), 253 patients with early glottic cancer underwent RT by 2-dimensional or 3-dimensional RT with 60Co or linear accelerator. Appropriate daily bolus was applied with linear accelerator-based RT to avoid under dosage of the anterior commissure. Results: A total of 253 patients with T1-T2 glottic cancer were treated with definitive RT. The median age was 65 and males made up 87% of the population. T1 was 77% of the population. The median dose and fraction size were 63 and 2.25 Gy, respectively. After a median followup of 83 months, the locoregional control (LRC) for the whole cohort was 98%. Specifically, LRCs for T1 (195 patients) and T2 (58 patients) were 99.5% and 91%, respectively. Kaplan-Meier curve shows the 5-year cause-specific survival to be 100%. Conclusions: Single-modality RT provides an excellent and effective treatment for T1-T2 glottic cancer with remarkable functional preservation and 5-year LRC of 98% with negligible long-term toxicity.
AB - Purpose: To evaluate the impact of radiation therapy (RT) on the longterm outcomes and pattern of failure for T1-2 glottic cancer. Materials and Methods: This is a single-institution, retrospective study. From January (1997 to 2010), 253 patients with early glottic cancer underwent RT by 2-dimensional or 3-dimensional RT with 60Co or linear accelerator. Appropriate daily bolus was applied with linear accelerator-based RT to avoid under dosage of the anterior commissure. Results: A total of 253 patients with T1-T2 glottic cancer were treated with definitive RT. The median age was 65 and males made up 87% of the population. T1 was 77% of the population. The median dose and fraction size were 63 and 2.25 Gy, respectively. After a median followup of 83 months, the locoregional control (LRC) for the whole cohort was 98%. Specifically, LRCs for T1 (195 patients) and T2 (58 patients) were 99.5% and 91%, respectively. Kaplan-Meier curve shows the 5-year cause-specific survival to be 100%. Conclusions: Single-modality RT provides an excellent and effective treatment for T1-T2 glottic cancer with remarkable functional preservation and 5-year LRC of 98% with negligible long-term toxicity.
KW - Early (T1-T2 true vocal cord) glottic cancer
KW - Radiation therapy
KW - Squamous cell carcinoma of the larynx
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UR - http://www.scopus.com/inward/citedby.url?scp=84892590223&partnerID=8YFLogxK
U2 - 10.1097/COC.0b013e318256f5fd
DO - 10.1097/COC.0b013e318256f5fd
M3 - Article
C2 - 22868239
AN - SCOPUS:84892590223
SN - 0277-3732
VL - 36
SP - 580
EP - 583
JO - American Journal of Clinical Oncology
JF - American Journal of Clinical Oncology
IS - 6
ER -
