"Look-ahead distance" of a fiber probe used to assist neurosurgery: Phantom and Monte Carlo study

Zhiyu Qian, Sunder S. Victor, Yueqing Gu, Cole A. Giller, Hanli Liu

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


A short-separation, optical reflectance probe has been developed to assist the neurosurgeon in functional neurosurgery for accurate localization of the surgical target. Because of the scattering nature of tissue, the optical probe has a "Look Ahead Distance" (LAD), at which the measured optical reflectance starts to "see" or "sense" the underlying brain structure due to the difference in light scattering of tissue. To quantify the LAD, 2-layer laboratory phantoms have been developed to mimic gray and white matter of the brain, and Monte Carlo simulations have been also used to confirm the experimental findings. Based on both the laboratory and simulation results, a quantitative empirical equation is developed to express the LAD as a function of scattering coefficient of the measured tissue for a 400-micron-diameter fiber probe. The quantified LAD of the probe is highly desirable so as to improve the spatial resolution of the probe for better surgery guidance.

Original languageEnglish (US)
Pages (from-to)1844-1855
Number of pages12
JournalOptics Express
Issue number16
StatePublished - Aug 2003
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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