Loss of host axons in nerve allografts after abolishing immunological tolerance in rats

Andrew A. Zalewski; Adarsh K. Gulati; Willys K. Silvers

doi:10.1016/0014-4886(81)90239-9

Loss of host axons in nerve allografts after abolishing immunological tolerance in rats

Andrew A. Zalewski, Adarsh K. Gulati, Willys K. Silvers

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Because host axons regenerate through long nerve allografts and become ensheathed by allogeneic cells in tolerant rats, we determined what would happen to these axons if tolerance were abolished. This was achieved by inoculating lymphoid cells from specifically sensitized isogenic donors into tolerant hosts. As a consequence of the immunological reaction which ensued, the host axons in the graft degenerated, indicating that permanent immunosuppression is required to maintain these fibers.

Original language	English (US)
Pages (from-to)	502-506
Number of pages	5
Journal	Experimental Neurology
Volume	72
Issue number	2
DOIs	https://doi.org/10.1016/0014-4886(81)90239-9
State	Published - May 1981
Externally published	Yes

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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title = "Loss of host axons in nerve allografts after abolishing immunological tolerance in rats",

abstract = "Because host axons regenerate through long nerve allografts and become ensheathed by allogeneic cells in tolerant rats, we determined what would happen to these axons if tolerance were abolished. This was achieved by inoculating lymphoid cells from specifically sensitized isogenic donors into tolerant hosts. As a consequence of the immunological reaction which ensued, the host axons in the graft degenerated, indicating that permanent immunosuppression is required to maintain these fibers.",

author = "Zalewski, {Andrew A.} and Gulati, {Adarsh K.} and Silvers, {Willys K.}",

note = "Funding Information: Abbreviations: LE-Lewis, BN-Brown Norway. 1 The authors wish to thank Mrs. Janina D. Ziemnowicz for histological assistance and Mrs. Sylvia Levinson for manuscript preparation. This research was supported in part by U.S. Public Health Service grant CA-15822 to Dr. Silvers.",

year = "1981",

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doi = "10.1016/0014-4886(81)90239-9",

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pages = "502--506",

journal = "Experimental Neurology",

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T1 - Loss of host axons in nerve allografts after abolishing immunological tolerance in rats

AU - Zalewski, Andrew A.

AU - Gulati, Adarsh K.

AU - Silvers, Willys K.

N1 - Funding Information: Abbreviations: LE-Lewis, BN-Brown Norway. 1 The authors wish to thank Mrs. Janina D. Ziemnowicz for histological assistance and Mrs. Sylvia Levinson for manuscript preparation. This research was supported in part by U.S. Public Health Service grant CA-15822 to Dr. Silvers.

PY - 1981/5

Y1 - 1981/5

N2 - Because host axons regenerate through long nerve allografts and become ensheathed by allogeneic cells in tolerant rats, we determined what would happen to these axons if tolerance were abolished. This was achieved by inoculating lymphoid cells from specifically sensitized isogenic donors into tolerant hosts. As a consequence of the immunological reaction which ensued, the host axons in the graft degenerated, indicating that permanent immunosuppression is required to maintain these fibers.

AB - Because host axons regenerate through long nerve allografts and become ensheathed by allogeneic cells in tolerant rats, we determined what would happen to these axons if tolerance were abolished. This was achieved by inoculating lymphoid cells from specifically sensitized isogenic donors into tolerant hosts. As a consequence of the immunological reaction which ensued, the host axons in the graft degenerated, indicating that permanent immunosuppression is required to maintain these fibers.

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JO - Experimental Neurology

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ER -

Loss of host axons in nerve allografts after abolishing immunological tolerance in rats

Abstract

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