TY - JOUR
T1 - Lubiprostone induced ischemic colitis
AU - Sherid, Muhammed
AU - Sifuentes, Humberto
AU - Samo, Salih
AU - Deepak, Parakkal
AU - Sridhar, Subbaramiah
PY - 2013
Y1 - 2013
N2 - Ischemic colitis accounts for 6%-18% of the causes of acute lower gastrointestinal bleeding. It is often multifactorial and more commonly encountered in the elderly. Several medications have been implicated in the development of colonic ischemia. We report a case of a 54-year old woman who presented with a two-hour history of nausea, vomiting, abdominal pain, and bloody stool. The patient had recently used lubiprostone with close temporal relationship between the increase in the dose and her symptoms of rectal bleeding. The radiologic, colonoscopic and histopathologic findings were all consistent with ischemic colitis. Her condition improved without any serious complications after the cessation of lubiprostone. This is the first reported case of ischemic colitis with a clear relationship with lubiprostone (Naranjo score of 10). Clinical vigilance for ischemic colitis is recommended for patients receiving lubiprostone who are presenting with abdominal pain and rectal bleeding.
AB - Ischemic colitis accounts for 6%-18% of the causes of acute lower gastrointestinal bleeding. It is often multifactorial and more commonly encountered in the elderly. Several medications have been implicated in the development of colonic ischemia. We report a case of a 54-year old woman who presented with a two-hour history of nausea, vomiting, abdominal pain, and bloody stool. The patient had recently used lubiprostone with close temporal relationship between the increase in the dose and her symptoms of rectal bleeding. The radiologic, colonoscopic and histopathologic findings were all consistent with ischemic colitis. Her condition improved without any serious complications after the cessation of lubiprostone. This is the first reported case of ischemic colitis with a clear relationship with lubiprostone (Naranjo score of 10). Clinical vigilance for ischemic colitis is recommended for patients receiving lubiprostone who are presenting with abdominal pain and rectal bleeding.
KW - Colonoscopy
KW - Gastrointestinal bleeding
KW - Ischemic colitis
KW - Lubiprostone
KW - Rectal bleeding
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U2 - 10.3748/wjg.v19.i2.299
DO - 10.3748/wjg.v19.i2.299
M3 - Article
C2 - 23345954
AN - SCOPUS:84873654410
SN - 1007-9327
VL - 19
SP - 299
EP - 303
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 2
ER -