Lymphocyte migration into atherosclerotic plaque

Jie Li, Klaus Ley

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations

Abstract

Adaptive immunity is involved in the pathogenesis of atherosclerosis, but the recruitment of T and B lymphocytes to atherosclerotic lesions is not as well studied as that of monocytes. In this review, we summarize the current understanding of the role of lymphocyte subsets in the pathogenesis of atherosclerosis and discuss chemokines and chemokine receptors involved in lymphocyte homing to atherosclerotic lesions. We review evidence for involvement of the chemokines CCL5, CCL19, CCL21, CXCL10, and CXCL16 and macrophage migration inhibitory factor in lymphocyte homing in atherosclerosis. Also, we review the role of their receptors CCR5, CCR6, CCR7, CXCR3, CXCR6, and CXCR2/CXCR4 and the role of the L-selectin in mouse models of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)40-49
Number of pages10
JournalArteriosclerosis, thrombosis, and vascular biology
Volume35
Issue number1
DOIs
StatePublished - Jan 3 2015
Externally publishedYes

Keywords

  • Atherosclerosis
  • CC chemokine receptor
  • Lymphocytes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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