Machine perfusion in kidney transplantation

Ashish Kataria, Sandeep Magoon, Binni Makkar, Aijaz Gundroo

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Purpose of reviewThe shortage of kidneys for transplantation has led to an urgent need to efficiently utilize the available cadaveric kidneys. Efficient use of machine perfusion may potentially lead to increased use of marginal kidneys by lowering the incidence of delayed graft function (DGF) and improving graft outcomes.Recent findingsMachine perfusion has had a resurgence in the last 10-15 years over static cold storage (SCS). Hypothermic machine perfusion (HMP), the most commonly utilized type of machine perfusion reduces the rates of DGF when compared with SCS with a trend towards improving the overall graft survival.SummaryDespite reduction in the rates of DGF by HMP, its effect on long-term renal and patient outcomes is not clearly known. There is limited clinical literature in the use of normothermic machine perfusion (NMP) but a few pilot studies have shown its potential to resuscitate commonly discarded kidneys. In addition to preservation, machine perfusion also allows for various diagnostic and therapeutic interventions during the preservation period to assess and optimize the viability of the procured kidney.

Original languageEnglish (US)
Pages (from-to)378-384
Number of pages7
JournalCurrent Opinion in Organ Transplantation
Volume24
Issue number4
DOIs
StatePublished - Aug 1 2019
Externally publishedYes

Keywords

  • delayed graft function
  • graft survival
  • hypothermic perfusion
  • machine perfusion
  • normothermic perfusion

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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