Malignant fibrous histiocytoma: Report of five cases and a review of the literature

Howard A. Zaren, Dominic Delaurentis, David L. Paskin, Harvey J. Lerner

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Five cases of malignant fibrous histiocytoma are presented and the relevant literature is reviewed. All the patients had locally extensive tumor or eventual recurrent or metastatic disease. Determining malignancy by histologic criteria is difficult. Therefore, histologic, gross, and clinical behavior of the tumor is important. Though the role of radiation therapy and chemotherapy is not yet established, it appears that at least wide “cancer resection,” if possible, is the treatment of choice. The unusually high incidence of nonresectable, recurrent, or metastatic disease in retroperitoneal histiocytomas raises the question as to whether all three modalities of therapy should be used in the treatment of tumors at this particular site.

Original languageEnglish (US)
Pages (from-to)431-439
Number of pages9
JournalJournal of Surgical Oncology
Issue number5
StatePublished - 1978
Externally publishedYes


  • malignant fibrous histiocytoma
  • multidiscipline treatment
  • sarcoma

ASJC Scopus subject areas

  • Surgery
  • Oncology


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