Manifestation and Mechanisms of Abnormal Mineralization in Teeth

Wen Qin, Qian Qian Wan, Yu Xuan Ma, Chen Yu Wang, Mei Chen Wan, Sai Ma, Yi Rong Wang, Wan Rong Wang, Jun Ting Gu, Franklin R. Tay, Li Na Niu

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Tooth biomineralization is a dynamic and complicated process influenced by local and systemic factors. Abnormal mineralization in teeth occurs when factors related to physiologic mineralization are altered during tooth formation and after tooth maturation, resulting in microscopic and macroscopic manifestations. The present Review provides timely information on the mechanisms and structural alterations of different forms of pathological tooth mineralization. A comprehensive study of these alterations benefits diagnosis and biomimetic treatment of abnormal mineralization in patients.

Original languageEnglish (US)
Pages (from-to)1733-1756
Number of pages24
JournalACS Biomaterials Science and Engineering
Issue number4
StatePublished - Apr 10 2023


  • ameloblasts
  • odontoblasts
  • pathological mineralization
  • teeth

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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