Maternal Alcohol Ingestion and Blood Cord IgE Concentrations

Mary Grzybowski; Dennis R. Ownby; Christine C. Johnson; Edward L. Peterson

doi:10.1089/pai.1995.9.193

Maternal Alcohol Ingestion and Blood Cord IgE Concentrations

Mary Grzybowski, Dennis R. Ownby, Christine C. Johnson, Edward L. Peterson

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Previous reports have implicated maternal ethanol ingestion as a cause of immunoglobulin abnormalities in children. We investigated the relationship between self-reported alcohol ingestion in 98 women during pregnancy and serum cord Immunoglobulin E (IgE). We found that mean cord IgE concentrations were significantly lower among newborns born to drinking mothers (0.15 IU/ml) than nondrinking mothers (0.27 IU/ml), p < 0.05. The difference of serum cord IgE means remained significant among infants with a positive family history of allergic disease, 0.15 IU/ml for infants of drinking mothers and 0.40 IU/ml of nondrinking mothers. There was a significant trend for lower mean cord IgE with increasing ethanol ingestion (p < 0.05). Maternal alcohol drinking should be considered a potential influence on cord blood IgE concentrations at birth.

Original language	English (US)
Pages (from-to)	193-198
Number of pages	6
Journal	Pediatric Asthma, Allergy and Immunology
Volume	9
Issue number	4
DOIs	https://doi.org/10.1089/pai.1995.9.193
State	Published - Jan 1 1995
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Immunology and Allergy
Pulmonary and Respiratory Medicine

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10.1089/pai.1995.9.193

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title = "Maternal Alcohol Ingestion and Blood Cord IgE Concentrations",

abstract = "Previous reports have implicated maternal ethanol ingestion as a cause of immunoglobulin abnormalities in children. We investigated the relationship between self-reported alcohol ingestion in 98 women during pregnancy and serum cord Immunoglobulin E (IgE). We found that mean cord IgE concentrations were significantly lower among newborns born to drinking mothers (0.15 IU/ml) than nondrinking mothers (0.27 IU/ml), p < 0.05. The difference of serum cord IgE means remained significant among infants with a positive family history of allergic disease, 0.15 IU/ml for infants of drinking mothers and 0.40 IU/ml of nondrinking mothers. There was a significant trend for lower mean cord IgE with increasing ethanol ingestion (p < 0.05). Maternal alcohol drinking should be considered a potential influence on cord blood IgE concentrations at birth.",

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AU - Grzybowski, Mary

AU - Ownby, Dennis R.

AU - Johnson, Christine C.

AU - Peterson, Edward L.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Previous reports have implicated maternal ethanol ingestion as a cause of immunoglobulin abnormalities in children. We investigated the relationship between self-reported alcohol ingestion in 98 women during pregnancy and serum cord Immunoglobulin E (IgE). We found that mean cord IgE concentrations were significantly lower among newborns born to drinking mothers (0.15 IU/ml) than nondrinking mothers (0.27 IU/ml), p < 0.05. The difference of serum cord IgE means remained significant among infants with a positive family history of allergic disease, 0.15 IU/ml for infants of drinking mothers and 0.40 IU/ml of nondrinking mothers. There was a significant trend for lower mean cord IgE with increasing ethanol ingestion (p < 0.05). Maternal alcohol drinking should be considered a potential influence on cord blood IgE concentrations at birth.

AB - Previous reports have implicated maternal ethanol ingestion as a cause of immunoglobulin abnormalities in children. We investigated the relationship between self-reported alcohol ingestion in 98 women during pregnancy and serum cord Immunoglobulin E (IgE). We found that mean cord IgE concentrations were significantly lower among newborns born to drinking mothers (0.15 IU/ml) than nondrinking mothers (0.27 IU/ml), p < 0.05. The difference of serum cord IgE means remained significant among infants with a positive family history of allergic disease, 0.15 IU/ml for infants of drinking mothers and 0.40 IU/ml of nondrinking mothers. There was a significant trend for lower mean cord IgE with increasing ethanol ingestion (p < 0.05). Maternal alcohol drinking should be considered a potential influence on cord blood IgE concentrations at birth.

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Maternal Alcohol Ingestion and Blood Cord IgE Concentrations

Abstract

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