Matrix Metalloproteinases and their Inhibitors - Friend or Foe

Mumtaz V. Rojiani, Marzenna Wiranowska, Amyn M. Rojiani

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
Original languageEnglish (US)
Title of host publicationTumor Microenvironment
PublisherJohn Wiley and Sons
Number of pages24
ISBN (Print)9780470749968
StatePublished - Aug 31 2010


  • Invasive and metastatic activities of cancer cells - contributing morbidity and mortality
  • MMP impact on tumor microenvironment and growth
  • Mammalian family of matrix metalloproteinases
  • Matrilysins, MMP-7 and MMP-26 - roles - in degradation and processing of ECM and non-ECM proteins
  • Matrix metalloproteinases and their inhibitors - friend or foe
  • Modulating change within physiologic and tumor microenvironment - matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs)
  • Pleiotropic nature of MMPs - diversity of functions in cancer progression
  • Targets and substrates of MMP action - cellular or extracellular
  • Tissue inhibitors of matrix metalloproteinases
  • Tumor-associated fibroblasts - role in cancer progression and angiogenesis

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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