TY - JOUR
T1 - Mature CD4+ T cells perceive a positively selecting class II MHC/peptide complex in the periphery
AU - Muranski, Pawel
AU - Chmielowski, Bartosz
AU - Ignatowicz, Leszek
PY - 2000/3/15
Y1 - 2000/3/15
N2 - A repertoire of TCRs is selected in the thymus by interactions with MHC bound to self-derived peptides. Whether self peptides bound to MHC influence the survival of mature T cells in the periphery remains enigmatic. In this study, we show that the number of naive CD4+ T cells that developed in mice with class II MHC bound with endogenous peptides (A(b)wt) diminished when transferred into mice with A(b) covalently bound with a single peptide (AbEp). Moreover, transfer of a mixture of naive CD4+ T cells derived from A(b)wt and from A(b)Ep mice into A(b)Ep mice resulted in the expansion of the latter and decline of the former. In contrast, when wild-type activated CD4+ T cells were transferred into AbEp or Abwt mice, these cells survived in both recipients for more than 4 wk, but further expanded in the Abwt host. We conclude that to survive, naive CD4+ T cells favor peripheral expression of the class II MHC/peptide complex(es) involved in their thymic selection, whereas some of activated CD4+ T cells may require them only for expansion.
AB - A repertoire of TCRs is selected in the thymus by interactions with MHC bound to self-derived peptides. Whether self peptides bound to MHC influence the survival of mature T cells in the periphery remains enigmatic. In this study, we show that the number of naive CD4+ T cells that developed in mice with class II MHC bound with endogenous peptides (A(b)wt) diminished when transferred into mice with A(b) covalently bound with a single peptide (AbEp). Moreover, transfer of a mixture of naive CD4+ T cells derived from A(b)wt and from A(b)Ep mice into A(b)Ep mice resulted in the expansion of the latter and decline of the former. In contrast, when wild-type activated CD4+ T cells were transferred into AbEp or Abwt mice, these cells survived in both recipients for more than 4 wk, but further expanded in the Abwt host. We conclude that to survive, naive CD4+ T cells favor peripheral expression of the class II MHC/peptide complex(es) involved in their thymic selection, whereas some of activated CD4+ T cells may require them only for expansion.
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U2 - 10.4049/jimmunol.164.6.3087
DO - 10.4049/jimmunol.164.6.3087
M3 - Article
C2 - 10706698
AN - SCOPUS:0034654092
SN - 0022-1767
VL - 164
SP - 3087
EP - 3094
JO - Journal of Immunology
JF - Journal of Immunology
IS - 6
ER -