Medical and psychiatric comorbidities: Complicating treatment expectations

Brian J. Miller, Peter F. Buckley

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Upon all outcomes, premature mortality is a profound consequence of medical and psychiatric (especially depression with suicidality) comorbidities. Additionally, obesity and metabolic disturbances substantially complicate the selection and duration of trial of subsequent antipsychotic medications. This is most pronounced with respect to clozapine, wherein obesity and metabolic dysfunction now predominate and powerful influence the use of this drug as well as adjunctive therapies.

Original languageEnglish (US)
Title of host publicationTreatment-Refractory Schizophrenia
Subtitle of host publicationA Clinical Conundrum
PublisherSpringer Berlin Heidelberg
Number of pages20
ISBN (Electronic)9783642452574
ISBN (Print)9783642452567
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Medicine(all)


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