TY - JOUR
T1 - Mesenteric Oxygenation Changes Associated with Necrotizing Enterocolitis and Pneumoperitoneum after Multiple Blood Transfusions
T2 - A Case Report
AU - Marin, Terri
AU - Moore, James E.
N1 - Funding Information:
This work was supported in part by the Florida Association of Neonatal Nurse Practitioners organization through an awarded grant to Dr Terri Marin.
Publisher Copyright:
© 2018 Lippincott Williams and Wilkins. All rights reserved.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Background: The multifactorial pathology and broad clinical presentation of necrotizing enterocolitis (NEC) development in premature infants make prediction of disease onset extremely challenging. Over the past decade, packed red blood cell (PRBC) transfusions have been temporally linked to the development of NEC in severely anemic preterm infants, although this issue is highly controversial. Purpose: In this case study, we describe events of an extremely low birth-weight infant who developed NEC complicated by pneumoperitoneum after receiving multiple PRBC transfusions. Specifically, we describe mesenteric tissue oxygenation trend changes as measured by continuous near-infrared spectroscopy (NIRS) technology. Methods: As part of a larger prospective, observational investigation, this infant was monitored with NIRS (INVOS 5100C; Medtronic, Boulder, Colorado) before, during, and 48 hours following PRBC transfusions. Results: The infant demonstrated severe, prolonged, and persistent reductions in mesenteric tissue oxygenation following blood transfusions, yet routine physiologic monitoring did not indicate intestinal hypoperfusion or impending NEC onset. Implications for Practice: This report demonstrates the ability of NIRS to capture possible tissue ischemia during early stages of NEC that may help guide bedside therapeutic interventions. Implications for Research: Larger cohort studies to evaluate the ability of NIRS to capture early tissue ischemia are essential to validate the feasibility of adding this technology as a routine clinical bedside tool. Video Abstract available at https://journals.lww.com/advancesinneonatalcare/Pages/videogallery.aspx.
AB - Background: The multifactorial pathology and broad clinical presentation of necrotizing enterocolitis (NEC) development in premature infants make prediction of disease onset extremely challenging. Over the past decade, packed red blood cell (PRBC) transfusions have been temporally linked to the development of NEC in severely anemic preterm infants, although this issue is highly controversial. Purpose: In this case study, we describe events of an extremely low birth-weight infant who developed NEC complicated by pneumoperitoneum after receiving multiple PRBC transfusions. Specifically, we describe mesenteric tissue oxygenation trend changes as measured by continuous near-infrared spectroscopy (NIRS) technology. Methods: As part of a larger prospective, observational investigation, this infant was monitored with NIRS (INVOS 5100C; Medtronic, Boulder, Colorado) before, during, and 48 hours following PRBC transfusions. Results: The infant demonstrated severe, prolonged, and persistent reductions in mesenteric tissue oxygenation following blood transfusions, yet routine physiologic monitoring did not indicate intestinal hypoperfusion or impending NEC onset. Implications for Practice: This report demonstrates the ability of NIRS to capture possible tissue ischemia during early stages of NEC that may help guide bedside therapeutic interventions. Implications for Research: Larger cohort studies to evaluate the ability of NIRS to capture early tissue ischemia are essential to validate the feasibility of adding this technology as a routine clinical bedside tool. Video Abstract available at https://journals.lww.com/advancesinneonatalcare/Pages/videogallery.aspx.
KW - NEC
KW - NIRS
KW - ischemia
KW - near-infrared spectroscopy
KW - necrotizing enterocolitis
KW - tissue oxygenation
KW - transfusion-related necrotizing enterocolitis
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U2 - 10.1097/ANC.0000000000000461
DO - 10.1097/ANC.0000000000000461
M3 - Article
C2 - 29300196
AN - SCOPUS:85045540307
SN - 1536-0903
VL - 18
SP - 121
EP - 127
JO - Advances in Neonatal Care
JF - Advances in Neonatal Care
IS - 2
ER -