Meta-analysis of erythrocyte na, K-ATPase activity in bipolar illness

Stephen W. Looney; Rif S. Ei-Mallakh

doi:10.1002/(SICI)1520-6394(1997)5:2<53::AID-DA1>3.0.CO;2-6

Meta-analysis of erythrocyte na, K-ATPase activity in bipolar illness

Stephen W. Looney, Rif S. Ei-Mallakh

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Sodium, potassium-activated adenosine tripbospbatase (Na, K-ATPase) pump activity has been variously reported to be increased, decreased, or unchanged in bipolar patients. To explore this association we conducted a meta-analysis of the available literature. All papers containing data on eiythrocyte Na, K-ATPase activity -were reviewed independently by both authors. A meta-analysis of these data was accomplished by standard procedure. We found a significant mood-state-related decrease in Na, K-ATPase activity in both manic and bipolar depressed patients when compared to euthymic bipolar patients, but not when ill patients were compared to normal controls. The overall change can be characterized as small to moderate in magnitude.

Original language	English (US)
Pages (from-to)	53-65
Number of pages	13
Journal	Depression and Anxiety
Volume	5
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1520-6394(1997)5:2<53::AID-DA1>3.0.CO;2-6
State	Published - 1997
Externally published	Yes

Keywords

Bipolar disorder
Effect size
Eiytbrocytes
Manic-depression
Metaanalysis
Na, K-ATPase

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/(SICI)1520-6394(1997)5:2<53::AID-DA1>3.0.CO;2-6

Cite this

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AU - Ei-Mallakh, Rif S.

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AB - Sodium, potassium-activated adenosine tripbospbatase (Na, K-ATPase) pump activity has been variously reported to be increased, decreased, or unchanged in bipolar patients. To explore this association we conducted a meta-analysis of the available literature. All papers containing data on eiythrocyte Na, K-ATPase activity -were reviewed independently by both authors. A meta-analysis of these data was accomplished by standard procedure. We found a significant mood-state-related decrease in Na, K-ATPase activity in both manic and bipolar depressed patients when compared to euthymic bipolar patients, but not when ill patients were compared to normal controls. The overall change can be characterized as small to moderate in magnitude.

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Meta-analysis of erythrocyte na, K-ATPase activity in bipolar illness

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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