TY - JOUR
T1 - Metabolic effects of isoflurane on rat lungs perfused in situ
AU - Martin, Dan C.
AU - Carr, Anne M.
AU - Watkins, Clyde A.
N1 - Funding Information:
Acknowledgement--This work was supported by HL 30187 from U.S.P.H.S.
PY - 1990
Y1 - 1990
N2 - 1. The current experiments studied the effects of the inhalation anesthetic, isoflurane, on 5-hydroxytryptamine (5-HT) metabolism, protein synthesis, and angiotensin-converting enzyme activity in perfused rat lungs. 2. Under first order reaction conditions, isoflurane decreased the accumulation of tissue 5-hydroxyindoleacetic acid, the principle metabolite of 5-HT in a concentration-related, competitive, and reversible manner, indicating inhibition of endothelial 5-HT uptake. 3. In apparent contrast, isoflurane appeared to stimulate uptake of 5-HT by an imipramine-sensitive process, into a cell type unable to metabolize the parent amine. 4. Isoflurane increased absolute angiotensin-converting enzyme activity only at an inspired concentration of 5%. The anesthetic did not affect lung protein synthesis.
AB - 1. The current experiments studied the effects of the inhalation anesthetic, isoflurane, on 5-hydroxytryptamine (5-HT) metabolism, protein synthesis, and angiotensin-converting enzyme activity in perfused rat lungs. 2. Under first order reaction conditions, isoflurane decreased the accumulation of tissue 5-hydroxyindoleacetic acid, the principle metabolite of 5-HT in a concentration-related, competitive, and reversible manner, indicating inhibition of endothelial 5-HT uptake. 3. In apparent contrast, isoflurane appeared to stimulate uptake of 5-HT by an imipramine-sensitive process, into a cell type unable to metabolize the parent amine. 4. Isoflurane increased absolute angiotensin-converting enzyme activity only at an inspired concentration of 5%. The anesthetic did not affect lung protein synthesis.
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U2 - 10.1016/0306-3623(90)90701-M
DO - 10.1016/0306-3623(90)90701-M
M3 - Article
C2 - 2165955
AN - SCOPUS:0025359616
SN - 0306-3623
VL - 21
SP - 477
EP - 481
JO - General Pharmacology
JF - General Pharmacology
IS - 4
ER -