Metal-Based Nanostructures/PLGA Nanocomposites: Antimicrobial Activity, Cytotoxicity, and Their Biomedical Applications

Ehsan Nazarzadeh Zare, Rezvan Jamaledin, Parvaneh Naserzadeh, Elham Afjeh-Dana, Behnaz Ashtari, Mehdi Hosseinzadeh, Raffaele Vecchione, Aimin Wu, Franklin R. Tay, Assunta Borzacchiello, Pooyan Makvandi

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations


Among the different synthetic polymers developed for biomedical applications, poly(lactic-co-glycolic acid) (PLGA) has attracted considerable attention because of its excellent biocompatibility and biodegradability. Nanocomposites based on PLGA and metal-based nanostructures (MNSs) have been employed extensively as an efficient strategy to improve the structural and functional properties of PLGA polymer. The MNSs have been used to impart new properties to PLGA, such as antimicrobial properties and labeling. In the present review, the different strategies available for the fabrication of MNS/PLGA nanocomposites and their applications in the biomedical field will be discussed, beginning with a description of the preparation routes, antimicrobial activity, and cytotoxicity concerns of MNS/PLGA nanocomposites. The biomedical applications of these nanocomposites, such as carriers and scaffolds in tissue regeneration and other therapies are subsequently reviewed. In addition, the potential advantages of using MNS/PLGA nanocomposites in treatment illnesses are analyzed based on in vitro and in vivo studies, to support the potential of these nanocomposites in future research in the biomedical field.

Original languageEnglish (US)
Pages (from-to)3279-3300
Number of pages22
JournalACS Applied Materials and Interfaces
Issue number3
StatePublished - Jan 22 2020


  • PLGA
  • antimicrobial activity
  • biomedical applications
  • cytotoxicity
  • metal-based nanostructures

ASJC Scopus subject areas

  • Materials Science(all)


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