TY - JOUR
T1 - MicroRNAs in extracellular vesicles protect kidney from ischemic injury
T2 - from endothelial to tubular epithelial
AU - Livingston, Man Jiang
AU - Wei, Qingqing
N1 - Publisher Copyright:
© 2016 International Society of Nephrology
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Extracellular vesicles from stem cells or progenitor cells are novel therapeutic systems for acute kidney injury. With exosomes (the smallest class of extracellular vesicles), Viñas et al. successfully rescued ischemic injured kidney. MicroRNA-486-5p, the crucial factor specifically delivered by exosomes to kidney, ameliorates the injury by targeting phosphatase and tensin homolog and inhibiting endothelial cell apoptosis. In this commentary, we discuss the potential underlying mechanism and the pivotal impact of their study on extracellular vesicle therapy.
AB - Extracellular vesicles from stem cells or progenitor cells are novel therapeutic systems for acute kidney injury. With exosomes (the smallest class of extracellular vesicles), Viñas et al. successfully rescued ischemic injured kidney. MicroRNA-486-5p, the crucial factor specifically delivered by exosomes to kidney, ameliorates the injury by targeting phosphatase and tensin homolog and inhibiting endothelial cell apoptosis. In this commentary, we discuss the potential underlying mechanism and the pivotal impact of their study on extracellular vesicle therapy.
UR - http://www.scopus.com/inward/record.url?scp=84997221501&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84997221501&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2016.08.032
DO - 10.1016/j.kint.2016.08.032
M3 - Comment/debate
C2 - 27884305
AN - SCOPUS:84997221501
SN - 0085-2538
VL - 90
SP - 1150
EP - 1152
JO - Kidney International
JF - Kidney International
IS - 6
ER -