MicroRNAs in extracellular vesicles protect kidney from ischemic injury: from endothelial to tubular epithelial

Man Jiang Livingston; Qingqing Wei

doi:10.1016/j.kint.2016.08.032

MicroRNAs in extracellular vesicles protect kidney from ischemic injury: from endothelial to tubular epithelial

Cellular Biology and Anatomy

Research output: Contribution to journal › Comment/debate › peer-review

13 Scopus citations

Abstract

Extracellular vesicles from stem cells or progenitor cells are novel therapeutic systems for acute kidney injury. With exosomes (the smallest class of extracellular vesicles), Viñas et al. successfully rescued ischemic injured kidney. MicroRNA-486-5p, the crucial factor specifically delivered by exosomes to kidney, ameliorates the injury by targeting phosphatase and tensin homolog and inhibiting endothelial cell apoptosis. In this commentary, we discuss the potential underlying mechanism and the pivotal impact of their study on extracellular vesicle therapy.

Original language	English (US)
Pages (from-to)	1150-1152
Number of pages	3
Journal	Kidney International
Volume	90
Issue number	6
DOIs	https://doi.org/10.1016/j.kint.2016.08.032
State	Published - Dec 1 2016

ASJC Scopus subject areas

Nephrology

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10.1016/j.kint.2016.08.032

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title = "MicroRNAs in extracellular vesicles protect kidney from ischemic injury: from endothelial to tubular epithelial",

abstract = "Extracellular vesicles from stem cells or progenitor cells are novel therapeutic systems for acute kidney injury. With exosomes (the smallest class of extracellular vesicles), Vi{\~n}as et al. successfully rescued ischemic injured kidney. MicroRNA-486-5p, the crucial factor specifically delivered by exosomes to kidney, ameliorates the injury by targeting phosphatase and tensin homolog and inhibiting endothelial cell apoptosis. In this commentary, we discuss the potential underlying mechanism and the pivotal impact of their study on extracellular vesicle therapy.",

author = "Livingston, \{Man Jiang\} and Qingqing Wei",

note = "Publisher Copyright: {\textcopyright} 2016 International Society of Nephrology",

year = "2016",

month = dec,

day = "1",

doi = "10.1016/j.kint.2016.08.032",

language = "English (US)",

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journal = "Kidney International",

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T1 - MicroRNAs in extracellular vesicles protect kidney from ischemic injury

T2 - from endothelial to tubular epithelial

AU - Livingston, Man Jiang

AU - Wei, Qingqing

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Extracellular vesicles from stem cells or progenitor cells are novel therapeutic systems for acute kidney injury. With exosomes (the smallest class of extracellular vesicles), Viñas et al. successfully rescued ischemic injured kidney. MicroRNA-486-5p, the crucial factor specifically delivered by exosomes to kidney, ameliorates the injury by targeting phosphatase and tensin homolog and inhibiting endothelial cell apoptosis. In this commentary, we discuss the potential underlying mechanism and the pivotal impact of their study on extracellular vesicle therapy.

AB - Extracellular vesicles from stem cells or progenitor cells are novel therapeutic systems for acute kidney injury. With exosomes (the smallest class of extracellular vesicles), Viñas et al. successfully rescued ischemic injured kidney. MicroRNA-486-5p, the crucial factor specifically delivered by exosomes to kidney, ameliorates the injury by targeting phosphatase and tensin homolog and inhibiting endothelial cell apoptosis. In this commentary, we discuss the potential underlying mechanism and the pivotal impact of their study on extracellular vesicle therapy.

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UR - https://www.scopus.com/pages/publications/84997221501#tab=citedBy

U2 - 10.1016/j.kint.2016.08.032

DO - 10.1016/j.kint.2016.08.032

M3 - Comment/debate

C2 - 27884305

AN - SCOPUS:84997221501

SN - 0085-2538

VL - 90

SP - 1150

EP - 1152

JO - Kidney International

JF - Kidney International

IS - 6

ER -

MicroRNAs in extracellular vesicles protect kidney from ischemic injury: from endothelial to tubular epithelial

Abstract

ASJC Scopus subject areas

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