Microwave assisted synthesis of spiro heterocyclic systems: A Review

Pankaj Khanna, Leena Khanna, Sean J. Thomas, Abdullah M. Asiri, Siva Shankar Panda

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Background: Microwave irradiation has emerged as a useful synthetic strategy for chemists and drug developers due to enhanced yields, regioselectivity, and faster reaction times. One area of importance in its practice has been the design of spiro compounds, which possess great interest on account of their natural occurrence and medicinal capabilities. The increasingly large number of these scaffolds and unlimited amount of methodologies utilized in their preparation have made them good candidates for the microwave assisted approach. Conclusion: Therefore, this review emphasizes the use of microwave irradiation in the synthesis of spiro heterocyclic compounds.

Original languageEnglish (US)
Pages (from-to)67-84
Number of pages18
JournalCurrent Organic Chemistry
Issue number1
StatePublished - 2018


  • Green synthesis
  • Heterocycles
  • Microwave
  • Spiro compounds

ASJC Scopus subject areas

  • Organic Chemistry


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