MiR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor

W. Y. Lam; Ariel C.Y. Cheung; Christine K.C. Tung; Apple C.M. Yeung; Karry L.K. Ngai; Vivian W.Y. Lui; Paul K.S. Chan; Stephen K.W. Tsui

doi:10.1016/j.febslet.2014.12.006

MiR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor

W. Y. Lam, Ariel C.Y. Cheung, Christine K.C. Tung, Apple C.M. Yeung, Karry L.K. Ngai, Vivian W.Y. Lui, Paul K.S. Chan, Stephen K.W. Tsui

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.

Original language	English (US)
Pages (from-to)	246-254
Number of pages	9
Journal	FEBS Letters
Volume	589
Issue number	2
DOIs	https://doi.org/10.1016/j.febslet.2014.12.006
State	Published - Jan 16 2015
Externally published	Yes

Keywords

Coxsackie B virus
Coxsackie virus and Adenovirus Receptor
microRNA

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/j.febslet.2014.12.006

Cite this

@article{2c5affd8f3c145409bcb0b58c9ad69e1,

title = "MiR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor",

abstract = "This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.",

keywords = "Coxsackie B virus, Coxsackie virus and Adenovirus Receptor, microRNA",

author = "Lam, {W. Y.} and Cheung, {Ariel C.Y.} and Tung, {Christine K.C.} and Yeung, {Apple C.M.} and Ngai, {Karry L.K.} and Lui, {Vivian W.Y.} and Chan, {Paul K.S.} and Tsui, {Stephen K.W.}",

year = "2015",

month = jan,

day = "16",

doi = "10.1016/j.febslet.2014.12.006",

language = "English (US)",

volume = "589",

pages = "246--254",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - MiR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor

AU - Lam, W. Y.

AU - Cheung, Ariel C.Y.

AU - Tung, Christine K.C.

AU - Yeung, Apple C.M.

AU - Ngai, Karry L.K.

AU - Lui, Vivian W.Y.

AU - Chan, Paul K.S.

AU - Tsui, Stephen K.W.

PY - 2015/1/16

Y1 - 2015/1/16

N2 - This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.

AB - This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.

KW - Coxsackie B virus

KW - Coxsackie virus and Adenovirus Receptor

KW - microRNA

UR - http://www.scopus.com/inward/record.url?scp=84920747667&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920747667&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2014.12.006

DO - 10.1016/j.febslet.2014.12.006

M3 - Article

C2 - 25497012

AN - SCOPUS:84920747667

SN - 0014-5793

VL - 589

SP - 246

EP - 254

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

MiR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this