MiR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor

W. Y. Lam; Ariel C.Y. Cheung; Christine K.C. Tung; Apple C.M. Yeung; Karry L.K. Ngai; Vivian W.Y. Lui; Paul K.S. Chan; Stephen K.W. Tsui

doi:10.1016/j.febslet.2014.12.006

MiR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor

W. Y. Lam
, Ariel C.Y. Cheung
, Christine K.C. Tung
, Apple C.M. Yeung
, Karry L.K. Ngai
, Vivian W.Y. Lui
, Paul K.S. Chan
, Stephen K.W. Tsui

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.

Original language	English (US)
Pages (from-to)	246-254
Number of pages	9
Journal	FEBS Letters
Volume	589
Issue number	2
DOIs	https://doi.org/10.1016/j.febslet.2014.12.006
State	Published - Jan 16 2015
Externally published	Yes

Keywords

Coxsackie B virus
Coxsackie virus and Adenovirus Receptor
microRNA

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2014.12.006

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title = "MiR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor",

abstract = "This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.",

keywords = "Coxsackie B virus, Coxsackie virus and Adenovirus Receptor, microRNA",

author = "Lam, \{W. Y.\} and Cheung, \{Ariel C.Y.\} and Tung, \{Christine K.C.\} and Yeung, \{Apple C.M.\} and Ngai, \{Karry L.K.\} and Lui, \{Vivian W.Y.\} and Chan, \{Paul K.S.\} and Tsui, \{Stephen K.W.\}",

year = "2015",

month = jan,

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doi = "10.1016/j.febslet.2014.12.006",

language = "English (US)",

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T1 - MiR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor

AU - Lam, W. Y.

AU - Cheung, Ariel C.Y.

AU - Tung, Christine K.C.

AU - Yeung, Apple C.M.

AU - Ngai, Karry L.K.

AU - Lui, Vivian W.Y.

AU - Chan, Paul K.S.

AU - Tsui, Stephen K.W.

PY - 2015/1/16

Y1 - 2015/1/16

N2 - This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.

AB - This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.

KW - Coxsackie B virus

KW - Coxsackie virus and Adenovirus Receptor

KW - microRNA

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DO - 10.1016/j.febslet.2014.12.006

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AN - SCOPUS:84920747667

SN - 0014-5793

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JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

MiR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor

Abstract

Keywords

ASJC Scopus subject areas

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