Model selection for DCE-T1 studies in glioblastoma

Hassan Bagher-Ebadian, Rajan Jain, Siamak P. Nejad-Davarani, Tom Mikkelsen, Mei Lu, Quan Jiang, Lisa Scarpace, Ali S. Arbab, Jayant Narang, Hamid Soltanian-Zadeh, Ramesh Paudyal, James R. Ewing

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Dynamic contrast enhanced T1-weighted MRI using the contrast agent gadopentetate dimeglumine (Gd-DTPA) was performed on 10 patients with glioblastoma. Nested models with as many as three parameters were used to estimate plasma volume or plasma volume and forward vascular transfer constant (Ktrans) and the reverse vascular transfer constant (kep). These constituted models 1, 2, and 3, respectively. Model 1 predominated in normal nonleaky brain tissue, showing little or no leakage of contrast agent. Model 3 predominated in regions associated with aggressive portions of the tumor, and model 2 bordered model 3 regions, showing leakage at reduced rates. In the patient sample, vp was about four times that of white matter in the enhancing part of the tumor. Ktrans varied by a factor of 10 between the model 2 (1.9 ↔ 10-3 min-1) and model 3 regions (1.9 ↔ 10-2 min-1). The mean calculated interstitial space (model 3) was 5.5%. In model 3 regions, excellent curve fits were obtained to summarize concentration-time data (mean R2 = 0.99). We conclude that the three parameters of the standard model are sufficient to fit dynamic contrast enhanced T1 data in glioblastoma under the conditions of the experiment.

Original languageEnglish (US)
Pages (from-to)241-251
Number of pages11
JournalMagnetic Resonance in Medicine
Issue number1
StatePublished - Jul 2012
Externally publishedYes


  • Glioma
  • Indicator pharmacokinetics
  • Vascular permeability

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Model selection for DCE-T1 studies in glioblastoma'. Together they form a unique fingerprint.

Cite this