TY - JOUR
T1 - Modeling 3D melt electrospinning writing by response surface methodology
AU - Dayan, Cem Balda
AU - Afghah, Ferdows
AU - Okan, Burcu Saner
AU - Yıldız, Mehmet
AU - Menceloglu, Yusuf
AU - Culha, Mustafa
AU - Koc, Bahattin
N1 - Funding Information:
This work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) [grant number 213M687 ]. We thank Adnan Tasdemir for assistance with the SEM work, Navid Khani for suggestions and comments that greatly improved the concept, and Ali Nadernezhad for his comments on the manuscript.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/6/15
Y1 - 2018/6/15
N2 - Three-dimensional (3D) melt electrospinning writing (MEW) is a promising technique for 3D printing of porous scaffolds with well-defined geometrical features. The diameter of electrospun fibers strongly affect the achievable resolution and consequently several other physical, mechanical, and structural properties of the fabricated scaffold. However, there are a few process parameters which significantly affect the size of electrospun fibers. In this study, response surface methodology (RSM) was used to investigate the critical and optimized process parameters and their interaction effects on the desired fiber diameter. Four process parameters, including collector speed, tip-to-collector distance, applied pressure, and voltage were studied considering their practical ranges. The results showed that all the parameters except the applied voltage had a significant effect on the printed fiber diameters. A generalized model for the interaction effects of the parameters was introduced which can be used as a framework for selecting the process parameters to achieve the desired fiber diameter. The developed model was validated by choosing random process parameters and printing three-dimensional scaffolds. The results confirm that the predicted fiber diameters match closely with the actual fiber diameters measured directly from the printed scaffold.
AB - Three-dimensional (3D) melt electrospinning writing (MEW) is a promising technique for 3D printing of porous scaffolds with well-defined geometrical features. The diameter of electrospun fibers strongly affect the achievable resolution and consequently several other physical, mechanical, and structural properties of the fabricated scaffold. However, there are a few process parameters which significantly affect the size of electrospun fibers. In this study, response surface methodology (RSM) was used to investigate the critical and optimized process parameters and their interaction effects on the desired fiber diameter. Four process parameters, including collector speed, tip-to-collector distance, applied pressure, and voltage were studied considering their practical ranges. The results showed that all the parameters except the applied voltage had a significant effect on the printed fiber diameters. A generalized model for the interaction effects of the parameters was introduced which can be used as a framework for selecting the process parameters to achieve the desired fiber diameter. The developed model was validated by choosing random process parameters and printing three-dimensional scaffolds. The results confirm that the predicted fiber diameters match closely with the actual fiber diameters measured directly from the printed scaffold.
KW - 3D melt electrospinning writing
KW - Parameter optimization
KW - Response surface methodology
KW - Three-dimensional scaffold printing
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U2 - 10.1016/j.matdes.2018.03.053
DO - 10.1016/j.matdes.2018.03.053
M3 - Article
AN - SCOPUS:85044935664
SN - 0264-1275
VL - 148
SP - 87
EP - 95
JO - Materials and Design
JF - Materials and Design
ER -