Abstract
The Wnt/β-catenin pathway is an evolutionarily conserved signaling pathway critical for several biological processes. An aberrant Wnt/β-catenin signaling is linked to several human diseases. Emerging studies have highlighted the regulatory role of the Wnt/β-catenin signaling pathway in normal physiological processes of parenchymal and hematopoietic cells. Recent studies have shown that the activation of Wnt/β-catenin pathway in dendritic cells (DCs) play a critical role in mucosal tolerance and suppression of chronic autoimmune pathologies. Alternatively, tumors activate Wnt/β-catenin pathway in DCs to induce immune tolerance and thereby evade antitumor immunity through suppression of effector T cell responses and promotion of regulatory T cell responses. Here, we review our work and current understanding of how Wnt/β-catenin signaling in DCs shapes the immune response in cancer and autoimmunity and discuss how Wnt/β-catenin pathway can be targeted for successful therapeutic interventions in various human diseases.
Original language | English (US) |
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Article number | 460 |
Journal | Frontiers in immunology |
Volume | 7 |
Issue number | OCT |
DOIs | |
State | Published - Oct 27 2016 |
Keywords
- Autoimmune diseases, antitumor immunity
- Dendritic cells
- Immune-tolerance
- Immuno-oncology
- Immunotherapy
- Wnt
- β-catenin
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology