Molecular epidemiology and evolution of West Nile virus in North America

Brian R. Mann; Allison R. McMullen; Daniele M. Swetnam; Alan D.T. Barrett

doi:10.3390/ijerph10105111

Molecular epidemiology and evolution of West Nile virus in North America

Brian R. Mann, Allison R. McMullen, Daniele M. Swetnam, Alan D.T. Barrett

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

West Nile virus (WNV) was introduced to New York in 1999 and rapidly spread throughout North America and into parts of Central and South America. Displacement of the original New York (NY99) genotype by the North America/West Nile 2002 (NA/WN02) genotype occurred in 2002 with subsequent identification of a novel genotype in 2003 in isolates collected from the southwestern Unites States region (SW/WN03 genotype). Both genotypes co-circulate to date. Subsequent WNV surveillance studies have confirmed additional genotypes in the United States that have become extinct due to lack of a selective advantage or stochastic effect; however, the dynamic emergence, displacement, and extinction of multiple WNV genotypes in the US from 1999-2012 indicates the continued evolution of WNV in North America.

Original language	English (US)
Pages (from-to)	5111-5129
Number of pages	19
Journal	International journal of environmental research and public health
Volume	10
Issue number	10
DOIs	https://doi.org/10.3390/ijerph10105111
State	Published - Oct 16 2013
Externally published	Yes

Keywords

Evolution
Molecular epidemiology
Phylogenetics
West Nile virus

ASJC Scopus subject areas

Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijerph10105111

Cite this

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title = "Molecular epidemiology and evolution of West Nile virus in North America",

abstract = "West Nile virus (WNV) was introduced to New York in 1999 and rapidly spread throughout North America and into parts of Central and South America. Displacement of the original New York (NY99) genotype by the North America/West Nile 2002 (NA/WN02) genotype occurred in 2002 with subsequent identification of a novel genotype in 2003 in isolates collected from the southwestern Unites States region (SW/WN03 genotype). Both genotypes co-circulate to date. Subsequent WNV surveillance studies have confirmed additional genotypes in the United States that have become extinct due to lack of a selective advantage or stochastic effect; however, the dynamic emergence, displacement, and extinction of multiple WNV genotypes in the US from 1999-2012 indicates the continued evolution of WNV in North America.",

keywords = "Evolution, Molecular epidemiology, Phylogenetics, West Nile virus",

author = "Mann, {Brian R.} and McMullen, {Allison R.} and Swetnam, {Daniele M.} and Barrett, {Alan D.T.}",

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doi = "10.3390/ijerph10105111",

language = "English (US)",

volume = "10",

pages = "5111--5129",

journal = "International journal of environmental research and public health",

issn = "1661-7827",

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number = "10",

}

TY - JOUR

T1 - Molecular epidemiology and evolution of West Nile virus in North America

AU - Mann, Brian R.

AU - McMullen, Allison R.

AU - Swetnam, Daniele M.

AU - Barrett, Alan D.T.

PY - 2013/10/16

Y1 - 2013/10/16

N2 - West Nile virus (WNV) was introduced to New York in 1999 and rapidly spread throughout North America and into parts of Central and South America. Displacement of the original New York (NY99) genotype by the North America/West Nile 2002 (NA/WN02) genotype occurred in 2002 with subsequent identification of a novel genotype in 2003 in isolates collected from the southwestern Unites States region (SW/WN03 genotype). Both genotypes co-circulate to date. Subsequent WNV surveillance studies have confirmed additional genotypes in the United States that have become extinct due to lack of a selective advantage or stochastic effect; however, the dynamic emergence, displacement, and extinction of multiple WNV genotypes in the US from 1999-2012 indicates the continued evolution of WNV in North America.

AB - West Nile virus (WNV) was introduced to New York in 1999 and rapidly spread throughout North America and into parts of Central and South America. Displacement of the original New York (NY99) genotype by the North America/West Nile 2002 (NA/WN02) genotype occurred in 2002 with subsequent identification of a novel genotype in 2003 in isolates collected from the southwestern Unites States region (SW/WN03 genotype). Both genotypes co-circulate to date. Subsequent WNV surveillance studies have confirmed additional genotypes in the United States that have become extinct due to lack of a selective advantage or stochastic effect; however, the dynamic emergence, displacement, and extinction of multiple WNV genotypes in the US from 1999-2012 indicates the continued evolution of WNV in North America.

KW - Evolution

KW - Molecular epidemiology

KW - Phylogenetics

KW - West Nile virus

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U2 - 10.3390/ijerph10105111

DO - 10.3390/ijerph10105111

M3 - Review article

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SN - 1661-7827

VL - 10

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EP - 5129

JO - International journal of environmental research and public health

JF - International journal of environmental research and public health

IS - 10

ER -

Molecular epidemiology and evolution of West Nile virus in North America

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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