TY - GEN
T1 - Momentum measure for quantifying dendritic cell movement
AU - Crockett, Caroline
AU - Orrico, Elizabeth
AU - McArdle, Sara
AU - Ley, Klaus
AU - Acton, Scott T.
N1 - Publisher Copyright:
© 2015 IEEE.
PY - 2016/2/26
Y1 - 2016/2/26
N2 - Discovery is ongoing regarding the causes and onset of atherosclerosis. Studying the movement of dendritic cells may provide insight to disease pathways and mechanisms, which will eventually lead to improved treatment. This paper develops an approach, inspired by momentum, to quantify the amount of quivering motion separately from translational motion. A simulation is developed to contrast the method performance against that of a graph-based approach. The resultant correlation coefficient between the simulated movement and the algorithm outcome is 0.85 for the proposed method, compared to 0.02 for a graph-based approach. In empirical tests, the momentum measure is shown to be robust to segmentation error.
AB - Discovery is ongoing regarding the causes and onset of atherosclerosis. Studying the movement of dendritic cells may provide insight to disease pathways and mechanisms, which will eventually lead to improved treatment. This paper develops an approach, inspired by momentum, to quantify the amount of quivering motion separately from translational motion. A simulation is developed to contrast the method performance against that of a graph-based approach. The resultant correlation coefficient between the simulated movement and the algorithm outcome is 0.85 for the proposed method, compared to 0.02 for a graph-based approach. In empirical tests, the momentum measure is shown to be robust to segmentation error.
KW - ath erosclerosis
KW - dendritic cells
KW - movement quantification
UR - http://www.scopus.com/inward/record.url?scp=84969848935&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84969848935&partnerID=8YFLogxK
U2 - 10.1109/ACSSC.2015.7421275
DO - 10.1109/ACSSC.2015.7421275
M3 - Conference contribution
AN - SCOPUS:84969848935
T3 - Conference Record - Asilomar Conference on Signals, Systems and Computers
SP - 935
EP - 939
BT - Conference Record of the 49th Asilomar Conference on Signals, Systems and Computers, ACSSC 2015
A2 - Matthews, Michael B.
PB - IEEE Computer Society
T2 - 49th Asilomar Conference on Signals, Systems and Computers, ACSSC 2015
Y2 - 8 November 2015 through 11 November 2015
ER -