TY - JOUR
T1 - Monocyte heterogeneity and functions in cancer
AU - Olingy, Claire E.
AU - Dinh, Huy Q.
AU - Hedrick, Catherine C.
N1 - Funding Information:
This work is supported by National Institutes of Health R01 CA202987
Funding Information:
C.E.O., H.Q.D., and C.C.H. all organized, wrote, and edited the review. This work is supported by National Institutes of Health R01 CA202987 and U01 CA224766 (both to C.C.H.).
Publisher Copyright:
©2019 The Authors. Society for Leukocyte Biology Published by Wiley Periodicals, Inc.
PY - 2019/8
Y1 - 2019/8
N2 - Monocytes are innate immune cells of the mononuclear phagocyte system that have emerged as important regulators of cancer development and progression. Our understanding of monocytes has advanced from viewing these cells as a homogenous population to a heterogeneous system of cells that display diverse responses to different stimuli. During cancer, different monocyte subsets perform functions that contribute to both pro- and antitumoral immunity, including phagocytosis, secretion of tumoricidal mediators, promotion of angiogenesis, remodeling of the extracellular matrix, recruitment of lymphocytes, and differentiation into tumor-associated macrophages and dendritic cells. The ability of cancer to evade immune recognition and clearance requires protumoral signals to outweigh ongoing attempts by the host immune system to prevent tumor growth. This review discusses current understanding of monocyte heterogeneity during homeostasis, highlights monocyte functions in cancer progression, and describes monocyte-targeted therapeutic strategies for cancer treatment.
AB - Monocytes are innate immune cells of the mononuclear phagocyte system that have emerged as important regulators of cancer development and progression. Our understanding of monocytes has advanced from viewing these cells as a homogenous population to a heterogeneous system of cells that display diverse responses to different stimuli. During cancer, different monocyte subsets perform functions that contribute to both pro- and antitumoral immunity, including phagocytosis, secretion of tumoricidal mediators, promotion of angiogenesis, remodeling of the extracellular matrix, recruitment of lymphocytes, and differentiation into tumor-associated macrophages and dendritic cells. The ability of cancer to evade immune recognition and clearance requires protumoral signals to outweigh ongoing attempts by the host immune system to prevent tumor growth. This review discusses current understanding of monocyte heterogeneity during homeostasis, highlights monocyte functions in cancer progression, and describes monocyte-targeted therapeutic strategies for cancer treatment.
KW - Monocytes
KW - cancer
KW - myeloid cells
KW - tumor microenvironment
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U2 - 10.1002/JLB.4RI0818-311R
DO - 10.1002/JLB.4RI0818-311R
M3 - Review article
C2 - 30776148
AN - SCOPUS:85061906903
SN - 0741-5400
VL - 106
SP - 309
EP - 322
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 2
ER -