TY - JOUR
T1 - Monocyte trafficking across the vessel wall
AU - Gerhardt, Teresa
AU - Ley, Klaus
N1 - Publisher Copyright:
© The Author 2015. All rights reserved.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Monocytes fundamentally contribute to immune surveillance and the inflammatory response in immunoinflammatory diseases like atherosclerosis. Recruitment of these cells to the site of injury requires their trafficking across the blood vessel wall. A series of events, including capture, rolling, slow rolling, arrest, adhesion strengthening, and lateral locomotion, precedemonocyte transmigration. Recent investigations have revealed new aspects of this cascade. This article revisits some conventional paradigms and selectively highlights new findings, including novel insights into monocyte differentiation and recently identified functional mediators, signalling pathways, and new structural aspects of monocyte extravasation. The emerging roles of endothelial junctional molecules like vascular endothelial-cadherin and the junctional adhesion molecule family, adhesion molecules such as intercellular adhesion molecule-1, molecules localized to the lateral border recycling compartment like cluster of differentiation 99, platelet/endothelial cell adhesion molecule-1, and poliovirus receptor (CD155), aswell as other cell surface molecules such as cluster of differentiation 146 and ephrins in transendothelial migration are discussed.
AB - Monocytes fundamentally contribute to immune surveillance and the inflammatory response in immunoinflammatory diseases like atherosclerosis. Recruitment of these cells to the site of injury requires their trafficking across the blood vessel wall. A series of events, including capture, rolling, slow rolling, arrest, adhesion strengthening, and lateral locomotion, precedemonocyte transmigration. Recent investigations have revealed new aspects of this cascade. This article revisits some conventional paradigms and selectively highlights new findings, including novel insights into monocyte differentiation and recently identified functional mediators, signalling pathways, and new structural aspects of monocyte extravasation. The emerging roles of endothelial junctional molecules like vascular endothelial-cadherin and the junctional adhesion molecule family, adhesion molecules such as intercellular adhesion molecule-1, molecules localized to the lateral border recycling compartment like cluster of differentiation 99, platelet/endothelial cell adhesion molecule-1, and poliovirus receptor (CD155), aswell as other cell surface molecules such as cluster of differentiation 146 and ephrins in transendothelial migration are discussed.
KW - Extravasation
KW - Monocyte migration
KW - Monocyte subsets
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U2 - 10.1093/cvr/cvv147
DO - 10.1093/cvr/cvv147
M3 - Review article
C2 - 25990461
AN - SCOPUS:84938527454
SN - 0008-6363
VL - 107
SP - 321
EP - 330
JO - Cardiovascular Research
JF - Cardiovascular Research
IS - 3
ER -