TY - JOUR
T1 - More frequent surveillance following lung cancer resection is not associated with improved survival
T2 - A nationally representative cohort study
AU - McMurry, Timothy L.
AU - Stukenborg, George J.
AU - Kessler, Larry G.
AU - Colditz, Graham A.
AU - Wong, Melisa L.
AU - Francescatti, Amanda B.
AU - Jones, David R.
AU - Schumacher, Jessica R.
AU - Greenberg, Caprice C.
AU - Chang, George J.
AU - Winchester, David P.
AU - McKellar, Daniel P.
AU - Kozower, Benjamin D.
N1 - Publisher Copyright:
Copyright ß 2018 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Objective: To evaluate whether an association exists between the intensity of surveillance following surgical resection for non–small cell lung cancer (NSCLC) and survival. Background: Surveillance guidelines following surgical resection of NSCLC vary widely and are based on expert opinion and limited evidence. Methods: A Special Study of the National Cancer Database randomly selected stage I to III NSCLC patients for data reabstraction. For patients diagnosed between 2006 and 2007 and followed for 5 years through 2012, registrars documented all postsurgical imaging with indication (routine surveillance, new symptoms), recurrence, new primary cancers, and survival, with 5-year follow-up. Patients were placed into surveillance groups according to existing guidelines (3-month, 6-month, annual). Overall survival and survival after recurrence were analyzed using Cox Proportional Hazards Models. Results: A total of 4463 patients were surveilled with computed tomography scans; these patients were grouped based on time from surgery to first surveillance. Groups were similar with respect to age, sex, comorbidities, surgical procedure, and histology. Higher-stage patients received more surveillance. More frequent surveillance was not associated with longer risk-adjusted overall survival [hazard ratio for 6-month: 1.16 (0.99, 1.36) and annual: 1.06 (0.86–1.31) vs 3-month; P value 0.14]. More frequent imaging was also not associated with postrecurrence survival [hazard ratio: 1.02/month since imaging (0.99–1.04); P value 0.43]. Conclusions: These nationally representative data provide evidence that more frequent postsurgical surveillance is not associated with improved survival. As the number of lung cancer survivors increases over the next decade, surveillance is an increasingly important major health care concern and expenditure.
AB - Objective: To evaluate whether an association exists between the intensity of surveillance following surgical resection for non–small cell lung cancer (NSCLC) and survival. Background: Surveillance guidelines following surgical resection of NSCLC vary widely and are based on expert opinion and limited evidence. Methods: A Special Study of the National Cancer Database randomly selected stage I to III NSCLC patients for data reabstraction. For patients diagnosed between 2006 and 2007 and followed for 5 years through 2012, registrars documented all postsurgical imaging with indication (routine surveillance, new symptoms), recurrence, new primary cancers, and survival, with 5-year follow-up. Patients were placed into surveillance groups according to existing guidelines (3-month, 6-month, annual). Overall survival and survival after recurrence were analyzed using Cox Proportional Hazards Models. Results: A total of 4463 patients were surveilled with computed tomography scans; these patients were grouped based on time from surgery to first surveillance. Groups were similar with respect to age, sex, comorbidities, surgical procedure, and histology. Higher-stage patients received more surveillance. More frequent surveillance was not associated with longer risk-adjusted overall survival [hazard ratio for 6-month: 1.16 (0.99, 1.36) and annual: 1.06 (0.86–1.31) vs 3-month; P value 0.14]. More frequent imaging was also not associated with postrecurrence survival [hazard ratio: 1.02/month since imaging (0.99–1.04); P value 0.43]. Conclusions: These nationally representative data provide evidence that more frequent postsurgical surveillance is not associated with improved survival. As the number of lung cancer survivors increases over the next decade, surveillance is an increasingly important major health care concern and expenditure.
KW - Computed tomography
KW - Non–small cell lung cancer
KW - Screening
KW - Surveillance
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U2 - 10.1097/SLA.0000000000002955
DO - 10.1097/SLA.0000000000002955
M3 - Article
C2 - 30004919
AN - SCOPUS:85058561885
SN - 0003-4932
VL - 268
SP - 632
EP - 639
JO - Annals of surgery
JF - Annals of surgery
IS - 4
ER -