TY - JOUR
T1 - Morphine inhibition of the insulin-inducible form of hepatic tyrosine aminotransferase
AU - Das, Sumantra
AU - Chatterjee, Tapan K.
AU - Ghosh, Jagat J.
N1 - Funding Information:
Acknowledgements--This work was financed from grants of the Indian Council of Medical Research, New Delhi. We express our appreciation to Dr. P. W. O'Connell of The Upjohn Co., Kalamazoo, MI, for the gift of streptozotocin.
PY - 1984/4/1
Y1 - 1984/4/1
N2 - Morphine treatment in normal intact rats caused a dose-dependent increase in hepatic tyrosine aminotransferase (TAT) activity, as demonstrable up to 2 hr of exposure to the opioid alkaloid. However, such increase in TAT activity was invariably preceded by a prior decline in the enzyme level, as observed after 15 min of morphine treatment. Such an initial decline in activity was not demonstrable in diabetic animals. Further studies indicate that morphine inhibited the insulin-induced increase in TAT activity, a phenomenon which could be reversed by the opioid antagonist naloxone. The results suggest an opioid control mechanism in the regulation of the insulin-inducible form of TAT and indicate the possibilities of a trophic role of endogenous opiates in gluconeogenesis.
AB - Morphine treatment in normal intact rats caused a dose-dependent increase in hepatic tyrosine aminotransferase (TAT) activity, as demonstrable up to 2 hr of exposure to the opioid alkaloid. However, such increase in TAT activity was invariably preceded by a prior decline in the enzyme level, as observed after 15 min of morphine treatment. Such an initial decline in activity was not demonstrable in diabetic animals. Further studies indicate that morphine inhibited the insulin-induced increase in TAT activity, a phenomenon which could be reversed by the opioid antagonist naloxone. The results suggest an opioid control mechanism in the regulation of the insulin-inducible form of TAT and indicate the possibilities of a trophic role of endogenous opiates in gluconeogenesis.
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U2 - 10.1016/0006-2952(84)90499-4
DO - 10.1016/0006-2952(84)90499-4
M3 - Article
C2 - 6143561
AN - SCOPUS:0021154935
SN - 0006-2952
VL - 33
SP - 951
EP - 954
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 7
ER -