Abstract
HLA-G was described originally as a tolerogenic molecule that allows the semiallogeneic fetus to escape from recognition by the maternal immune response. This review will discuss different steps in the study of HLA-G expression and functions in vivo, starting with analyses of expression of the HLA-G gene and its receptors in transgenic mice, and continuing with applications of HLA-G and its receptors in prevention of allograft rejection, transplantation tolerance, and controlling the development of infection. Humanized mouse models have been discussed for developing in vivo studies of HLA-G in physiological and pathological conditions. Collectively, animal models provide an opportunity to evaluate the importance of the interaction between HLA-G and its receptors in terms of its ability to regulate immune responses during maternal-fetal tolerance, survival of allografts, tumor-escape mechanisms, and development of infections when both HLA-G and its receptors are expressed. In addition, in vivo studies on HLA-G also offer novel approaches to achieve a reproducible transplantation tolerance and to develop personalized medicine to prevent allograft rejection.
Original language | English (US) |
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Pages (from-to) | 711-719 |
Number of pages | 9 |
Journal | Human Immunology |
Volume | 77 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2016 |
Keywords
- HLA-G
- Humanized mice
- Transgenic mice
- Transplantation
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology