MRI detection of myocardial perfusion changes by gadolinium‐DTPA infusion during dipyridamole hyperemia

D. Douglas Miller; Godtfred Holmvang; John B. Gill; Donna Dragotakes; Howard L. Kantor; Robert D. Okada; Thomas J. Brady

doi:10.1002/mrm.1910100209

MRI detection of myocardial perfusion changes by gadolinium‐DTPA infusion during dipyridamole hyperemia

D. Douglas Miller, Godtfred Holmvang, John B. Gill, Donna Dragotakes, Howard L. Kantor, Robert D. Okada, Thomas J. Brady

Research output: Contribution to journal › Article › peer-review

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Abstract

To detect abnormal regional myocardial coronary flow reserve, serial spin‐echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a bolus plus infusion of gadolinium‐DTPA. Microsphere myocardial blood flow was measured for correlation with serial regional changes in MR signal intensity. Significant difference in gadolinium‐enhanced MR signal intensity existed between the hypoperfused LAD and the hyperemic left circumflex perfusion beds (46 ± 22% vs 78 ± 29% above baseline, respectively; P < 0.05). The percentage changes in gadolinium‐enhanced MR signal and microsphere myocardial blood flow were significantly correlated (r² = 0.93). © 1989 Academic Press, Inc.

Original language	English (US)
Pages (from-to)	246-255
Number of pages	10
Journal	Magnetic Resonance in Medicine
Volume	10
Issue number	2
DOIs	https://doi.org/10.1002/mrm.1910100209
State	Published - May 1989
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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title = "MRI detection of myocardial perfusion changes by gadolinium‐DTPA infusion during dipyridamole hyperemia",

abstract = "To detect abnormal regional myocardial coronary flow reserve, serial spin‐echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a bolus plus infusion of gadolinium‐DTPA. Microsphere myocardial blood flow was measured for correlation with serial regional changes in MR signal intensity. Significant difference in gadolinium‐enhanced MR signal intensity existed between the hypoperfused LAD and the hyperemic left circumflex perfusion beds (46 ± 22% vs 78 ± 29% above baseline, respectively; P < 0.05). The percentage changes in gadolinium‐enhanced MR signal and microsphere myocardial blood flow were significantly correlated (r2 = 0.93). {\textcopyright} 1989 Academic Press, Inc.",

author = "Miller, {D. Douglas} and Godtfred Holmvang and Gill, {John B.} and Donna Dragotakes and Kantor, {Howard L.} and Okada, {Robert D.} and Brady, {Thomas J.}",

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AU - Miller, D. Douglas

AU - Holmvang, Godtfred

AU - Gill, John B.

AU - Dragotakes, Donna

AU - Kantor, Howard L.

AU - Okada, Robert D.

AU - Brady, Thomas J.

PY - 1989/5

Y1 - 1989/5

N2 - To detect abnormal regional myocardial coronary flow reserve, serial spin‐echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a bolus plus infusion of gadolinium‐DTPA. Microsphere myocardial blood flow was measured for correlation with serial regional changes in MR signal intensity. Significant difference in gadolinium‐enhanced MR signal intensity existed between the hypoperfused LAD and the hyperemic left circumflex perfusion beds (46 ± 22% vs 78 ± 29% above baseline, respectively; P < 0.05). The percentage changes in gadolinium‐enhanced MR signal and microsphere myocardial blood flow were significantly correlated (r2 = 0.93). © 1989 Academic Press, Inc.

AB - To detect abnormal regional myocardial coronary flow reserve, serial spin‐echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a bolus plus infusion of gadolinium‐DTPA. Microsphere myocardial blood flow was measured for correlation with serial regional changes in MR signal intensity. Significant difference in gadolinium‐enhanced MR signal intensity existed between the hypoperfused LAD and the hyperemic left circumflex perfusion beds (46 ± 22% vs 78 ± 29% above baseline, respectively; P < 0.05). The percentage changes in gadolinium‐enhanced MR signal and microsphere myocardial blood flow were significantly correlated (r2 = 0.93). © 1989 Academic Press, Inc.

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MRI detection of myocardial perfusion changes by gadolinium‐DTPA infusion during dipyridamole hyperemia

Abstract

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