Multifaceted Roles of Long Non-coding RNAs in Head and Neck Cancer

Leslie Duncan, Chloe Shay, Yong Teng

Research output: Chapter in Book/Report/Conference proceedingChapter


The majority of RNA transcripts are non-coding RNA (ncRNA) transcripts with lengths exceeding 200 nucleotides that are not translated into protein. Unlike microRNAs (miRNAs), long ncRNAs (lncRNAs) are not confined to a single mechanism of action but have a large and diverse role in biological processes as they can function as transcription regulators, decoys, scaffolds, and enhancer RNAs. Currently, many lncRNA molecules are under investigation for their role in tumorigenesis, metastasis, and prognosis in different types of cancer. This review not only summarizes the characteristics and functions of lncRNAs but also discusses the therapeutic implications and applications of lncRNAs with roles associated with head and neck cancer. Our aim is to pinpoint the potential way to perturb specific lncRNAs for future therapeutic use.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages8
StatePublished - 2021
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Head and neck cancer
  • Roles and functions
  • lncRNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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