TY - CHAP
T1 - Multifaceted Roles of Long Non-coding RNAs in Head and Neck Cancer
AU - Duncan, Leslie
AU - Shay, Chloe
AU - Teng, Yong
N1 - Funding Information:
Acknowledgments This work was supported in part by NIH grant (R03DE028387 and R01DE028351), Augusta University CURS Summer Scholars, and the Department of Medicine’s Translational Research Program.
Publisher Copyright:
© 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2021
Y1 - 2021
N2 - The majority of RNA transcripts are non-coding RNA (ncRNA) transcripts with lengths exceeding 200 nucleotides that are not translated into protein. Unlike microRNAs (miRNAs), long ncRNAs (lncRNAs) are not confined to a single mechanism of action but have a large and diverse role in biological processes as they can function as transcription regulators, decoys, scaffolds, and enhancer RNAs. Currently, many lncRNA molecules are under investigation for their role in tumorigenesis, metastasis, and prognosis in different types of cancer. This review not only summarizes the characteristics and functions of lncRNAs but also discusses the therapeutic implications and applications of lncRNAs with roles associated with head and neck cancer. Our aim is to pinpoint the potential way to perturb specific lncRNAs for future therapeutic use.
AB - The majority of RNA transcripts are non-coding RNA (ncRNA) transcripts with lengths exceeding 200 nucleotides that are not translated into protein. Unlike microRNAs (miRNAs), long ncRNAs (lncRNAs) are not confined to a single mechanism of action but have a large and diverse role in biological processes as they can function as transcription regulators, decoys, scaffolds, and enhancer RNAs. Currently, many lncRNA molecules are under investigation for their role in tumorigenesis, metastasis, and prognosis in different types of cancer. This review not only summarizes the characteristics and functions of lncRNAs but also discusses the therapeutic implications and applications of lncRNAs with roles associated with head and neck cancer. Our aim is to pinpoint the potential way to perturb specific lncRNAs for future therapeutic use.
KW - Head and neck cancer
KW - Roles and functions
KW - lncRNA
UR - http://www.scopus.com/inward/record.url?scp=85102855727&partnerID=8YFLogxK
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U2 - 10.1007/978-3-030-55035-6_7
DO - 10.1007/978-3-030-55035-6_7
M3 - Chapter
C2 - 33725348
AN - SCOPUS:85102855727
T3 - Advances in Experimental Medicine and Biology
SP - 107
EP - 114
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -
