Multimodal hyperspectral imaging for the noninvasive diagnosis of cervical neoplasia

Daron G. Ferris; Raymond A. Lawhead; Eileen D. Dickman; Nina Holtzapple; Jill A. Miller; Stephanie Grogan; Shabbir Bambot; Anant Agrawal; Mark L. Faupel

doi:10.1046/j.1526-0976.2001.005002065.x

Multimodal hyperspectral imaging for the noninvasive diagnosis of cervical neoplasia

Daron G. Ferris, Raymond A. Lawhead, Eileen D. Dickman, Nina Holtzapple, Jill A. Miller, Stephanie Grogan, Shabbir Bambot, Anant Agrawal, Mark L. Faupel

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

156 Scopus citations

Abstract

Objective. To determine the ability of Multimodal Hyperspectral Imaging (MHI) to noninvasively detect, localize and diagnose cervical neoplasia. Materials and methods. The cervical epithelium was interrogated by MHI using tissue fluorescence and reflectance measurements after the probe was placed on the ectocervix. A Papanicolaou smear was taken, and a colposcopic examination was performed and cervical histologic specimens were collected, when indicated. MHI and Pap smear sensitivity and specificity data were compared with colposcopic and histologic results. Results. Nineteen patients had CIN2 or higher, 30 had CIN1, 34 had benign cellular changes or metaplasia, and 28 were normal by both Pap smear and colposcopic examination. At equal specificity (70%) for both tests, the sensitivity of MHI was 97%, compared to 72% for the Pap smear. Conclusion. MHI detected cervical cancer precursors at a rate greater than that obtained by a simultaneously collected Pap smear.

Original language	English (US)
Pages (from-to)	65-72
Number of pages	8
Journal	Journal of Lower Genital Tract Disease
Volume	5
Issue number	2
DOIs	https://doi.org/10.1046/j.1526-0976.2001.005002065.x
State	Published - 2001

Keywords

Cervical neoplasia
Multimodal Hyperspectral imaging
Noninvasive diagnosis
Papanicolaou smear

ASJC Scopus subject areas

Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1046/j.1526-0976.2001.005002065.x

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title = "Multimodal hyperspectral imaging for the noninvasive diagnosis of cervical neoplasia",

abstract = "Objective. To determine the ability of Multimodal Hyperspectral Imaging (MHI) to noninvasively detect, localize and diagnose cervical neoplasia. Materials and methods. The cervical epithelium was interrogated by MHI using tissue fluorescence and reflectance measurements after the probe was placed on the ectocervix. A Papanicolaou smear was taken, and a colposcopic examination was performed and cervical histologic specimens were collected, when indicated. MHI and Pap smear sensitivity and specificity data were compared with colposcopic and histologic results. Results. Nineteen patients had CIN2 or higher, 30 had CIN1, 34 had benign cellular changes or metaplasia, and 28 were normal by both Pap smear and colposcopic examination. At equal specificity (70%) for both tests, the sensitivity of MHI was 97%, compared to 72% for the Pap smear. Conclusion. MHI detected cervical cancer precursors at a rate greater than that obtained by a simultaneously collected Pap smear.",

keywords = "Cervical neoplasia, Multimodal Hyperspectral imaging, Noninvasive diagnosis, Papanicolaou smear",

author = "Ferris, {Daron G.} and Lawhead, {Raymond A.} and Dickman, {Eileen D.} and Nina Holtzapple and Miller, {Jill A.} and Stephanie Grogan and Shabbir Bambot and Anant Agrawal and Faupel, {Mark L.}",

year = "2001",

doi = "10.1046/j.1526-0976.2001.005002065.x",

language = "English (US)",

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T1 - Multimodal hyperspectral imaging for the noninvasive diagnosis of cervical neoplasia

AU - Ferris, Daron G.

AU - Lawhead, Raymond A.

AU - Dickman, Eileen D.

AU - Holtzapple, Nina

AU - Miller, Jill A.

AU - Grogan, Stephanie

AU - Bambot, Shabbir

AU - Agrawal, Anant

AU - Faupel, Mark L.

PY - 2001

Y1 - 2001

N2 - Objective. To determine the ability of Multimodal Hyperspectral Imaging (MHI) to noninvasively detect, localize and diagnose cervical neoplasia. Materials and methods. The cervical epithelium was interrogated by MHI using tissue fluorescence and reflectance measurements after the probe was placed on the ectocervix. A Papanicolaou smear was taken, and a colposcopic examination was performed and cervical histologic specimens were collected, when indicated. MHI and Pap smear sensitivity and specificity data were compared with colposcopic and histologic results. Results. Nineteen patients had CIN2 or higher, 30 had CIN1, 34 had benign cellular changes or metaplasia, and 28 were normal by both Pap smear and colposcopic examination. At equal specificity (70%) for both tests, the sensitivity of MHI was 97%, compared to 72% for the Pap smear. Conclusion. MHI detected cervical cancer precursors at a rate greater than that obtained by a simultaneously collected Pap smear.

AB - Objective. To determine the ability of Multimodal Hyperspectral Imaging (MHI) to noninvasively detect, localize and diagnose cervical neoplasia. Materials and methods. The cervical epithelium was interrogated by MHI using tissue fluorescence and reflectance measurements after the probe was placed on the ectocervix. A Papanicolaou smear was taken, and a colposcopic examination was performed and cervical histologic specimens were collected, when indicated. MHI and Pap smear sensitivity and specificity data were compared with colposcopic and histologic results. Results. Nineteen patients had CIN2 or higher, 30 had CIN1, 34 had benign cellular changes or metaplasia, and 28 were normal by both Pap smear and colposcopic examination. At equal specificity (70%) for both tests, the sensitivity of MHI was 97%, compared to 72% for the Pap smear. Conclusion. MHI detected cervical cancer precursors at a rate greater than that obtained by a simultaneously collected Pap smear.

KW - Cervical neoplasia

KW - Multimodal Hyperspectral imaging

KW - Noninvasive diagnosis

KW - Papanicolaou smear

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Multimodal hyperspectral imaging for the noninvasive diagnosis of cervical neoplasia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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