Multimodality Imaging in a Depressed Patient with Violent Behavior and Temporal Lobe Seizures

T. J. Poprawski, A. N. Pluzyczka, Y. Park, V. N. Chennamchetty, A. Halaris, J. W. Crayton, L. M. Konopka

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Patients suffering from epilepsy commonly experience behavioral symptoms. Behavioral manifestations are especially prevalent in patients with seizures originating in the limbic system. This case report illustrates how an objective, multimodality work-up can guide the clinician in the diagnosis and the treatment of a patient with a complex presentation. After the discontinuation of some medications, the patient underwent a multimodality work-up that consisted of MRI, SPECT, and conventional and quantitative EEG (LORETA). In this case, the functional imaging studies showed a convergence of findings across the three modalities: MRI, SPECT and qEEG. Because of these findings, we supported more aggressive treatment of the seizure disorder. Ultimately this treatment resulted in resolution of the aggression and the depression. In summary, when applied routinely, a comprehensive, systematic, diagnostic approach will minimize treatment false starts and failures, may reduce costs, and also, potentially decrease the severity and the duration of symptoms.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
Journalclinical eeg and neuroscience
Issue number3
StatePublished - Jul 2007
Externally publishedYes


  • Depression
  • Electroencephalography
  • Multimodality Imaging
  • Temporal Lobe Seizures
  • Violent Behavior

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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