Multiple immunologic pathogeneses for inflammatory diseases of the colon

Bruce S. Rabin, Gurmukh Singh

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


There has been no clear indication, although there have been many indirect suggestiona, that inflammatory diseases of the colon are due to immune activation against antigens of the colon. It is possible that inflammatory diseaeses of the colon have different etiologies and pathogeneses. Such etiologic differences may require different therapeutic approaches. The following paper will give experimental evidence which indicates that there are at least three different immunologic etiologies which can produce inflammatory colonic disease. This must be taken as a minimum number of etiologies and does not preclude the possibility that non-immunologic mechanisms may also produce these diseases.

Original languageEnglish (US)
Pages (from-to)261-270
Number of pages10
JournalMedical Hypotheses
Issue number2
StatePublished - Feb 1981
Externally publishedYes


  • Inflammatory Bowel Disease and Immunity

ASJC Scopus subject areas

  • Medicine(all)


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